ONECUT1

one cut homeobox 1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1S7E
Identifiers
Aliases	ONECUT1, HNF-6, HNF6, HNF6A
External IDs	MGI: 1196423 HomoloGene: 3309 GeneCards: 3175
Gene ontology Molecular function • DNA binding • transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding Cellular component • cell nucleus Biological process • Notch signaling pathway • epithelial cell development • cell differentiation • cell fate commitment • endoderm development • regulation of transcription, DNA-templated • positive regulation of cell migration • regulation of transcription from RNA polymerase II promoter • anatomical structure morphogenesis • negative regulation of transforming growth factor beta receptor signaling pathway • spleen development • transcription from RNA polymerase II promoter • transcription, DNA-templated • regulation of cell-matrix adhesion • glucose metabolic process • pancreas development • cilium assembly • liver development • B cell differentiation • endocrine pancreas development • positive regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3175	15379
Ensembl	ENSG00000169856	ENSMUSG00000043013
UniProt	Q9UBC0 U3KQR8	O08755
RefSeq (mRNA)	XR_931803 NM_004498 NR_073510 XM_011521482 XM_011521483 XM_011521484 XM_011521485 XM_011521486 XM_011521487 XR_931800 XR_931801 XR_931802	NM_008262
RefSeq (protein)	NP_004489.1	NP_032288.1
Location (UCSC)	Chr 15: 52.76 – 52.79 Mb	Chr 9: 74.86 – 74.89 Mb
PubMed search
Wikidata

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One cut homeobox 1 is a protein that in humans is encoded by the ONECUT1 gene. ^[1]

Function

This gene encodes a member of the Cut homeobox family of transcription factors. Expression of the encoded protein is enriched in the liver, where it stimulates transcription of liver-expressed genes, and antagonizes glucocorticoid-stimulated gene transcription. This gene may influence a variety of cellular processes including glucose metabolism, cell cycle regulation, and it may also be associated with cancer. Alternative splicing results in multiple transcript variants.

References

1. "Entrez Gene: One cut homeobox 1". Retrieved 2016-04-13.

Further reading

• Rausa FM, Tan Y, Costa RH (2003). "Association between hepatocyte nuclear factor 6 (HNF-6) and FoxA2 DNA binding domains stimulates FoxA2 transcriptional activity but inhibits HNF-6 DNA binding". Mol. Cell. Biol. 23 (2): 437–49. PMC 151533. PMID 12509444.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.