ORM1

Orosomucoid 1
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3KQ0​
Identifiers
Symbols	ORM1 ; AGP-A; AGP1; HEL-S-153w; ORM
External IDs	OMIM: 138600 MGI: 97445 HomoloGene: 128040 ChEMBL: 4285 GeneCards: ORM1 Gene
Gene ontology Molecular function • protein binding Cellular component • extracellular region • extracellular space • extracellular exosome • blood microparticle Biological process • regulation of immune system process • transport • acute-phase response • inflammatory response • negative regulation of interleukin-6 production • negative regulation of tumor necrosis factor production Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5004	18405
Ensembl	ENSG00000229314	ENSMUSG00000039196
UniProt	P02763	Q60590
RefSeq (mRNA)	NM_000607	NM_008768.1
RefSeq (protein)	NP_000598	NP_032794.1
Location (UCSC)	Chr 9: 114.32 – 114.33 Mb	Chr 4: 63.01 – 63.01 Mb
PubMed search

Alpha-1-acid glycoprotein 1 is a protein that in humans is encoded by the ORM1 gene.^[1]

This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved in aspects of immunosuppression.^[1]

Interactions

ORM1 has been shown to interact with Plasminogen activator inhibitor-1.^[2]

See also

• Orosomucoid

References

1. "Entrez Gene: ORM1 orosomucoid 1".
2. Boncela, J; Papiewska I; Fijalkowska I; Walkowiak B; Cierniewski C S (Sep 2001). "Acute phase protein alpha 1-acid glycoprotein interacts with plasminogen activator inhibitor type 1 and stabilizes its inhibitory activity". J. Biol. Chem. (United States) 276 (38): 35305–11. doi:10.1074/jbc.M104028200. ISSN 0021-9258. PMID 11418606.

Further reading

• Treuheit MJ, Costello CE, Halsall HB (1992). "Analysis of the five glycosylation sites of human alpha 1-acid glycoprotein.". Biochem. J. 283 (1): 105–12. PMC 1131000. PMID 1567356.
• Dente L, Ciliberto G, Cortese R (1985). "Structure of the human alpha 1-acid glycoprotein gene: sequence homology with other human acute phase protein genes.". Nucleic Acids Res. 13 (11): 3941–52. doi:10.1093/nar/13.11.3941. PMC 341288. PMID 2409529.
• Dubé JY, Paradis G, Têtu B, Tremblay RR (1989). "Synthesis of alpha 1-acid glycoprotein by the human prostate.". Prostate 15 (3): 251–8. doi:10.1002/pros.2990150305. PMID 2479939.
• Zuffardi O, Caiulo A, Maraschio P, et al. (1989). "Regional assignment of the loci for adenylate kinase to 9q32 and for alpha 1-acid glycoprotein to 9q31-q32. A locus for Goltz syndrome in region 9q32-qter?". Hum. Genet. 82 (1): 17–9. doi:10.1007/bf00288264. PMID 2541064.
• Dente L, Pizza MG, Metspalu A, Cortese R (1987). "Structure and expression of the genes coding for human alpha 1-acid glycoprotein.". EMBO J. 6 (8): 2289–96. PMC 553631. PMID 2822385.
• Merritt CM, Board PG (1988). "Structure and characterisation of a duplicated human alpha 1 acid glycoprotein gene.". Gene 66 (1): 97–106. doi:10.1016/0378-1119(88)90228-4. PMID 2970990.
• Dente L, Rüther U, Tripodi M, et al. (1988). "Expression of human alpha 1-acid glycoprotein genes in cultured cells and in transgenic mice.". Genes Dev. 2 (2): 259–66. doi:10.1101/gad.2.2.259. PMID 3360326.
• Rocchi M, Roncuzzi L, Santamaria R, et al. (1986). "Mapping through somatic cell hybrids and cDNA probes of protein C to chromosome 2, factor X to chromosome 13, and alpha 1-acid glycoprotein to chromosome 9.". Hum. Genet. 74 (1): 30–3. doi:10.1007/BF00278781. PMID 3463531.
• Board PG, Jones IM, Bentley AK (1986). "Molecular cloning and nucleotide sequence of human alpha 1 acid glycoprotein cDNA.". Gene 44 (1): 127–31. doi:10.1016/0378-1119(86)90051-X. PMID 3770479.
• Krauss E, Polnaszek CF, Scheeler DA, et al. (1987). "Interaction between human serum albumin and alpha 1-acid glycoprotein in the binding of lidocaine to purified protein fractions and sera.". J. Pharmacol. Exp. Ther. 239 (3): 754–9. PMID 3795040.
• Ikenaka T, Ishiguro M, Emura J, et al. (1972). "Isolation and partial characterization of the cyanogen bromide fragments of 1 -acid glycoprotein and the elucidation of the amino acid sequence of the carboxyl-terminal cyanogen bromide fragment.". Biochemistry 11 (20): 3817–29. doi:10.1021/bi00770a022. PMID 4561179.
• Schmid K, Bürgi W, Collins JH, Nanno S (1974). "The disulfide bonds of alpha1-acid glycoprotein.". Biochemistry 13 (13): 2694–7. doi:10.1021/bi00710a006. PMID 4603214.
• Schmid K, Kaufmann H, Isemura S, et al. (1973). "Structure of 1 -acid glycoprotein. The complete amino acid sequence, multiple amino acid substitutions, and homology with the immunoglobulins.". Biochemistry 12 (14): 2711–24. doi:10.1021/bi00738a026. PMID 4711474.
• Mbuyi JM, Dequeker J, Bloemmen F, Stevens E (1982). "Plasma proteins in human cortical bone: enrichment of alpha 2 HS-glycoprotein, alpha 1 acid-glycoprotein, and IgE.". Calcif. Tissue Int. 34 (3): 229–31. doi:10.1007/BF02411242. PMID 6809283.
• Rabehi L, Ferriere F, Saffar L, Gattegno L (1995). "alpha 1-Acid glycoprotein binds human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein via N-linked glycans.". Glycoconj. J. 12 (1): 7–16. doi:10.1007/BF00731863. PMID 7795416.
• Matoba R, Okubo K, Hori N, et al. (1994). "The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression.". Gene 146 (2): 199–207. doi:10.1016/0378-1119(94)90293-3. PMID 8076819.
• Nakamura T, Board PG, Matsushita K, et al. (1993). "Alpha 1-acid glycoprotein expression in human leukocytes: possible correlation between alpha 1-acid glycoprotein and inflammatory cytokines in rheumatoid arthritis.". Inflammation 17 (1): 33–45. doi:10.1007/BF00916390. PMID 8432561.
• Yuasa I, Umetsu K, Vogt U, et al. (1997). "Human orosomucoid polymorphism: molecular basis of the three common ORM1 alleles, ORM1*F1, ORM1*F2, and ORM1*S.". Hum. Genet. 99 (3): 393–8. doi:10.1007/s004390050378. PMID 9050929.
• Morin D, Simon N, Deprés-Brummer P, et al. (1997). "Melatonin high-affinity binding to alpha-1-acid glycoprotein in human serum.". Pharmacology 54 (5): 271–5. doi:10.1159/000139495. PMID 9380773.
• Nakamura H, Yuasa I, Umetsu K, et al. (2000). "The rearrangement of the human alpha(1)-acid glycoprotein/orosomucoid gene: evidence for tandemly triplicated genes consisting of two AGP1 and one AGP2.". Biochem. Biophys. Res. Commun. 276 (2): 779–84. doi:10.1006/bbrc.2000.3522. PMID 11027547.