OST4
| Oligosaccaryltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 nmr structure of yeast oligosaccharyltransferase subunit ost4p | |||||||||
| Identifiers | |||||||||
| Symbol | Ost4 | ||||||||
| Pfam | PF10215 | ||||||||
| InterPro | IPR018943 | ||||||||
| OPM superfamily | 274 | ||||||||
| OPM protein | 2lat | ||||||||
| |||||||||
In molecular biology, OST4 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4) is a subunit of the oligosaccharyltransferase complex.[1] OST4 is a very short, approximately 30 amino acids, protein found from fungi to vertebrates. It appears to be an integral membrane protein that mediates the en bloc transfer of a pre-assembled high-mannose oligosaccharide onto asparagine residues of nascent polypeptides as they enter the lumen of the rough endoplasmic reticulum.[2][3]
References
- ↑ Kelleher DJ, Gilmore R (2006). "An evolving view of the eukaryotic oligosaccharyltransferase.". Glycobiology 16 (4): 47R–62R. doi:10.1093/glycob/cwj066. PMID 16317064.
- ↑ Gayen S, Kang C (2011). "Solution structure of a human minimembrane protein Ost4, a subunit of the oligosaccharyltransferase complex.". Biochem Biophys Res Commun 409 (3): 572–6. doi:10.1016/j.bbrc.2011.05.050. PMID 21609714.
- ↑ Spirig U, Bodmer D, Wacker M, Burda P, Aebi M (2005). "The 3.4-kDa Ost4 protein is required for the assembly of two distinct oligosaccharyltransferase complexes in yeast.". Glycobiology 15 (12): 1396–406. doi:10.1093/glycob/cwj025. PMID 16096346.
This article incorporates text from the public domain Pfam and InterPro IPR018943
This article is issued from Wikipedia - version of the Sunday, September 23, 2012. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.