OTUB2

OTU deubiquitinase, ubiquitin aldehyde binding 2
PDB rendering based on 1tff.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1TFF​, 4FJV​
Identifiers
Symbols	OTUB2 ; C14orf137; OTB2; OTU2
External IDs	OMIM: 608338 MGI: 1915399 HomoloGene: 57056 GeneCards: OTUB2 Gene
EC number	3.4.19.12
Gene ontology Molecular function • ubiquitin-specific protease activity • protein binding • NEDD8-specific protease activity • ubiquitin binding Cellular component • nucleus Biological process • protein deubiquitination • protein K11-linked deubiquitination • protein K63-linked deubiquitination • protein K48-linked deubiquitination Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	78990	68149
Ensembl	ENSG00000089723	ENSMUSG00000021203
UniProt	Q96DC9	Q9CQX0
RefSeq (mRNA)	NM_023112	NM_001177841
RefSeq (protein)	NP_075601	NP_001171312
Location (UCSC)	Chr 14: 94.03 – 94.05 Mb	Chr 12: 103.39 – 103.41 Mb
PubMed search

Ubiquitin thioesterase OTUB2 is an enzyme that in humans is encoded by the OTUB2 gene.^[1][2]

Otubains are deubiquitinating cysteine proteases (DUBs; see MIM 602519) that belong to the ovarian tumor (OTU) protein superfamily. Like other DUBs, otubains cleave proteins precisely at the ubiquitin (UB; see MIM 191339)-protein bond.^[2]

References

1. Balakirev MY, Tcherniuk SO, Jaquinod M, Chroboczek J (Apr 2003). "Otubains: a new family of cysteine proteases in the ubiquitin pathway". EMBO Rep 4 (5): 517–22. doi:10.1038/sj.embor.embor824. PMC 1319179. PMID 12704427.
2. "Entrez Gene: OTUB2 OTU domain, ubiquitin aldehyde binding 2".

Further reading

• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Nanao MH, Tcherniuk SO, Chroboczek J, et al. (2005). "Crystal structure of human otubain 2.". EMBO Rep. 5 (8): 783–8. doi:10.1038/sj.embor.7400201. PMC 1299112. PMID 15258613.
• Namciu SJ, Friedman RD, Marsden MD, et al. (2004). "Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1.". Mamm. Genome 15 (3): 162–78. doi:10.1007/s00335-003-2311-y. PMID 15014966.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14.". Nature 421 (6923): 601–7. doi:10.1038/nature01348. PMID 12508121.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.