Olivetolic acid cyclase

Olivetolic acid cyclase (EC 4.4.1.26, OAC) is an enzyme with systematic name 3,5,7-trioxododecanoyl-CoA CoA-lyase (2,4-dihydroxy-6-pentylbenzoate-forming).^[1] This enzyme catalyses the following chemical reaction

3,5,7-trioxododecanoyl-CoA

\rightleftharpoons

CoA + 2,4-dihydroxy-6-pentylbenzoate

This enzymes participates in the cannabinoids biosynthesis in the plant Cannabis sativa.

References

↑ Gagne, S.J., Stout, J.M., Liu, E., Boubakir, Z., Clark, S.M. and Page, J.E. (2012). "Identification of olivetolic acid cyclase from Cannabis sativa reveals a unique catalytic route to plant polyketides". Proc. Natl. Acad. Sci. USA 109: 12811–12816. doi:10.1073/pnas.1200330109. PMID 22802619.

External links

Olivetolic acid cyclase at the US National Library of Medicine Medical Subject Headings (MeSH)

Carbon-sulfur lyases (EC 4.4)

4.4.1	Cystathionine gamma-lyase Cystathionine beta-lyase Leukotriene C4 synthase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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