Organic cation transport proteins

An organic cation transport protein mediates the transport of organic cations across the cell membrane. These proteins are members of the solute carrier family, subfamily 22. This family of proteins can also transport zwitterions and anions, though it is a different subfamily of solute carrier proteins than the organic anion transporters.

Proteins

Abbreviation	Protein name	Location	Transported solute(s)	Associated disorder(s)
SLC22A1	Solute carrier family 22 member 1	Liver, Brain (Cerebellum)
SLC22A2	Solute carrier family 22 member 2	Primarily in kidney, also in brain
SLC22A3	Solute carrier family 22 member 3	Brain and kidney	Histamine Dopamine Serotonin Norepinephrine MPP+
SLC22A4	Solute carrier family 22 member 4		Sodium ion and Ergothioneine
SLC22A5	Solute carrier family 22 member 5			Primary carnitine deficiency
SLC22A6	Solute carrier family 22 member 6
SLC22A7	Solute carrier family 22 member 7
SLC22A8	Solute carrier family 22 member 8
SLC22A9	Solute carrier family 22 member 9
SLC22A10	Solute carrier family 22 member 10
SLC22A11	Solute carrier family 22 member 11
SLC22A12	Solute carrier family 22 member 12	Kidney	Uric acid	Hyperuricemia and hypouricemia
SLC22A13	Solute carrier family 22 member 13
SLC22A14	Solute carrier family 22 member 14
SLC22A15	Solute carrier family 22 member 15
SLC22A16	Solute carrier family 22 member 16
SLC22A17	Solute carrier family 22 member 17
SLC22A18	Solute carrier family 22 member 18			Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer
SLC22A19	Solute carrier family 22 member 19
SLC22A20	Solute carrier family 22 member 20