Osnat Penn

Osnat Penn is an Israeli computational biologist. Penn is the third Israeli scientist in three years to win the UNESCO-L’Oréal fellowship, which she received in 2013 for her work on the genetic origins of autism.[1] Penn is currently at the University of Washington in Seattle.[2]

Penn has been responsible for several different computer programs developed at Tel Aviv University in order to aid in biological research.[3] GUIDANCE is a web server used for estimating alignment confidence scores.[4][5] RASER, the RAte Shift EstimatoR, is used to test site-specific evolutionary rate shifts.[6] The Pepitope Server is used to map epitopes using affinity-selected peptides.[7] Her work with autism genetic sequencing which won her the UNESCO-L’Oréal award, worked to identify where there were genetic variations that linked to individuals displaying autism.[8] Her work will also lead to prenatal screening and early diagnosis of autism.[8]

Penn has been published in Cell,[9] Genome Research,[10] Molecular Biology and Evolution,[11] Nucleic Acids Research,[5] Systematic Biology,[12] BMC Evolutionary Biology,[13] PLoS Computational Biology,[14] Bioinformatics,[15] and Proteins.[16]

References

  1. ↑ "Israeli Autism Researcher Wins UNESCO Fellowship". Algemeiner. 29 March 2013. Retrieved 26 November 2015.
  2. ↑ "Osnat Penn". Eichler Lab. University of Washington. Retrieved 26 November 2015.
  3. ↑ "Osnat Penn". Tel Aviv University. Retrieved 26 November 2015.
  4. ↑ "The GUIDANCE Server". Tel Aviv University. Retrieved 26 November 2015.
  5. 1 2 Penn, Osnat; Privman, Eyal; Ashkenazy, Haim; Landan, Giddy; Graur, Dan; Pupko, Tal (2010-07-01). "GUIDANCE: a web server for assessing alignment confidence scores". Nucleic Acids Research 38 (suppl 2): W23–W28. doi:10.1093/nar/gkq443. ISSN 0305-1048. PMC 2896199. PMID 20497997.
  6. ↑ "RASER". Tel Aviv University. Retrieved 26 November 2015.
  7. ↑ "The Pepitope Server". Tel Aviv University. Retrieved 26 November 2015.
  8. 1 2 Kaplan, Michael (31 March 2013). "Autisme : Osnat Zomer-Penn gagne le prix l'OREAL-UNESCO 2013". Israel Valley (in French). Retrieved 26 November 2015.
  9. ↑ Bernier, Raphael; Golzio, Christelle; Xiong, Bo; Stessman, Holly A.; Coe, Bradley P.; Penn, Osnat; Witherspoon, Kali; Gerdts, Jennifer; Baker, Carl. "Disruptive CHD8 Mutations Define a Subtype of Autism Early in Development". Cell 158 (2): 263–276. doi:10.1016/j.cell.2014.06.017. ISSN 0092-8674. PMC 4136921. PMID 24998929.
  10. ↑ Gelfman, Sahar; Burstein, David; Penn, Osnat; Savchenko, Anna; Amit, Maayan; Schwartz, Schraga; Pupko, Tal; Ast, Gil (2012-01-01). "Changes in exon–intron structure during vertebrate evolution affect the splicing pattern of exons". Genome Research 22 (1): 35–50. doi:10.1101/gr.119834.110. ISSN 1088-9051. PMC 3246205. PMID 21974994.
  11. ↑ Privman, Eyal; Penn, Osnat; Pupko, Tal (2012-01-01). "Improving the Performance of Positive Selection Inference by Filtering Unreliable Alignment Regions". Molecular Biology and Evolution 29 (1): 1–5. doi:10.1093/molbev/msr177. ISSN 0737-4038. PMID 21772063.
  12. ↑ Stern, Adi; Mayrose, Itay; Penn, Osnat; Shaul, Shaul; Gophna, Uri; Pupko, Tal (2010-03-01). "An Evolutionary Analysis of Lateral Gene Transfer in Thymidylate Synthase Enzymes". Systematic Biology 59 (2): 212–225. doi:10.1093/sysbio/syp104. ISSN 1063-5157. PMC 2826268. PMID 20525631.
  13. ↑ Blanga-Kanfi, Shani; Miranda, Hector; Penn, Osnat; Pupko, Tal; DeBry, Ronald W.; Huchon, Dorothée (2009-04-02). "Rodent phylogeny revised: analysis of six nuclear genes from all major rodent clades". BMC Evolutionary Biology 9 (1): 71. doi:10.1186/1471-2148-9-71. ISSN 1471-2148. PMC 2674048. PMID 19341461.
  14. ↑ Penn, Osnat; Stern, Adi; Rubinstein, Nimrod D.; Dutheil, Julien; Bacharach, Eran; Galtier, Nicolas; Pupko, Tal (2008-11-07). "Evolutionary Modeling of Rate Shifts Reveals Specificity Determinants in HIV-1 Subtypes". PLoS Comput Biol 4 (11): e1000214. doi:10.1371/journal.pcbi.1000214. PMC 2566816. PMID 18989394.
  15. ↑ Mayrose, Itay; Penn, Osnat; Erez, Elana; Rubinstein, Nimrod D.; Shlomi, Tomer; Freund, Natalia Tarnovitski; Bublil, Erez M.; Ruppin, Eytan; Sharan, Roded (2007-12-01). "Pepitope: epitope mapping from affinity-selected peptides". Bioinformatics 23 (23): 3244–3246. doi:10.1093/bioinformatics/btm493. ISSN 1367-4803. PMID 17977889.
  16. ↑ Bublil, Erez M.; Freund, Natalia Tarnovitski; Mayrose, Itay; Penn, Osnat; Roitburd-Berman, Anna; Rubinstein, Nimrod D.; Pupko, Tal; Gershoni, Jonathan M. (2007-07-01). "Stepwise prediction of conformational discontinuous B-cell epitopes using the Mapitope algorithm". Proteins: Structure, Function, and Bioinformatics 68 (1): 294–304. doi:10.1002/prot.21387. ISSN 1097-0134.

External links

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