Otic polyp

An otic polyp (also called aural polyp) is a benign proliferation of chronic inflammatory cells associated with granulation tissue, in response to a longstanding inflammatory process of the middle ear.[1][2]

Otic (aural) polyp
Classification and external resources
MedlinePlus 001638

Signs and symptoms

Patients usually present with otorrhea, conductive hearing loss, and otalgia, while bleeding and a sensation of a mass are much less common.[2]

Imaging findings

Although imaging is not required to yield a diagnosis, it may be obtained to exclude other disorders, such as a concurrent cholesteatoma.

Pathology findings

An intermediate magnification of a H&E stained biopsy from an otic polyp.

By gross description, there is usually a solitary, polypoid, reddish mass behind an intact ear drum (typmanic membrane). The tissue is often friable, measuring <2 cm in most cases. All tissue should be processed in order to exclude a concurrent cholesteatoma.[3]

By microscopic exam, the polypoid appearance is maintained, showing a granulation-type tissue reaction with edematous stroma and a rich investment by capillaries. The surface of the polyp is covered by stratified squamous epitehlium with a prominent granular cell layer. The tissue is filled with lymphocytes, plasma cells, mast cells, histiocytes, and eosinophils. It is not uncommon to see plasma cells with Russell bodies and Mott cell formation. Depending on length of symptoms, multinucleated giant cells and calcifications may be seen. Other disorders may be concurrently present, especially since this is a post infectious/inflammatory disorder, and these include a cholesterol granuloma, "tunnel clusters" (glandular epithelial inclusions below the surface epithelium), and cholesteatoma.[3][4][5]

Immunohistochemistry

Immunohistochemistry is unnecessary for the diagnosis, but will highlight a mixed B- and T-cell population within the lymphoid component, without light chain (kappa or lambda) restriction. Any muscle markers would be negative.

Differential diagnoses

The lesion presents in young patients, so the differential for a "polyp", especially when the lymphoid component is crushed or dominant, would include a rhabdomyosarcoma, extramedullary plasmacytoma, and a neuroendocrine adenoma of the middle ear.

Management

Since this lesion is usually a complication of long standing otitis media, it is important to use an appropriate antibiotic therapy regimen. If the patient fails first line antibiotics, then second-line therapies should be employed, especially after appropriate culture and sensitivity testing. Surgery may be required if there is extension into the mastoid bone, or if a concurrent cholesteatoma is identified during surgery or biopsy. In general, patients have an excellent outcome after appropriate therapy.[1][2][3]

Epidemiology

This is an uncommon lesion, usually affecting young patients (mean age, 30 years), with a male to female ratio of 2:1. The middle ear is involved, although it may extend to the external auditory canal if there is tympanic membrane perforation.[1][2][3]

References

  1. 1 2 3 Prasannaraj, T.; De, N. S.; Narasimhan, I. (2003). "Aural polyps: Safe or unsafe disease?". American journal of otolaryngology 24 (3): 155–158. PMID 12761701.
  2. 1 2 3 4 Gliklich, R. E.; Cunningham, M. J.; Eavey, R. D. (1993). "The cause of aural polyps in children". Archives of otolaryngology--head & neck surgery 119 (6): 669–671. PMID 8499099.
  3. 1 2 3 4 Friedmann, I. (1990). "Pathological lesions of the external auditory meatus: A review". Journal of the Royal Society of Medicine 83 (1): 34–37. PMC 1292463. PMID 2406442.
  4. ↑ Nair, S.; Watts, S.; Flood, L. (2006). "Fibroblast growth factor receptor expression in aural polyps: Predictor of cholesteatoma?". The Journal of Laryngology & Otology 118 (5): 338–342. doi:10.1258/002221504323086507. PMID 15165306.
  5. ↑ Hussain, S. S.; Hopkinson, J. M. (1995). "Mast cells in aural polyps: A preliminary report". The Journal of laryngology and otology 109 (6): 491–494. PMID 7543918.

Further reading

Lester D. R. Thompson, Bruce M Wenig (2011). Diagnostic Pathology: Head and Neck: Published by Amirsys. Hagerstown, MD: Lippincott Williams & Wilkins. pp. 7:16–17. ISBN 1-931884-61-7. 

This article is issued from Wikipedia - version of the Friday, August 28, 2015. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.