Outer membrane efflux proteins
| Outer membrane efflux protein | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 | |||||||||
| Identifiers | |||||||||
| Symbol | OEP | ||||||||
| Pfam | PF02321 | ||||||||
| InterPro | IPR003423 | ||||||||
| SCOP | 1ek9 | ||||||||
| SUPERFAMILY | 1ek9 | ||||||||
| TCDB | 1.B.17 | ||||||||
| OPM superfamily | 34 | ||||||||
| OPM protein | 1yc9 | ||||||||
| |||||||||
Proteins in the outer membrane efflux protein family form trimeric channels that allow export of a variety of substrates in Gram negative bacteria. Each member of this family is composed of two repeats. The trimeric channel is composed of a 12 stranded beta-barrel that spans the outer membrane, and a long all helical barrel that spans the periplasm.
Examples include the Escherichia coli TolC outer membrane protein, which is required for proper expression of outer membrane protein genes; the Rhizobium nodulation protein; and the Pseudomonas FusA protein, which is involved in resistance to fusaric acid.
References
- Johnson, J. M.; Church, G. M. (1999). "Alignment and structure prediction of divergent protein families: Periplasmic and outer membrane proteins of bacterial efflux pumps". Journal of Molecular Biology 287 (3): 695–715. doi:10.1006/jmbi.1999.2630. PMID 10092468.
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