Spider lamb syndrome

Spider lamb syndrome, also known as spider syndrome[1] and more formally as ovine hereditary chondrodysplasia,[2] is a homozygous recessive disorder affecting the growth of cartilage and bone in sheep. It is a semilethal trait,[3] which is thought to have been first observed in the 1970s,[4] and is most common in sheep of the Suffolk and Hampshire breeds.[5] The mutation which causes spider lamb syndrome is found on Ovine Chromosome 6,[6] and involves the inactivation of fibroblast growth factor receptor 3.[7]

Afflicted animals may be visibly deformed at birth and unable to stand, or seemingly normal for the first 4 to 6 weeks of their life.[3]

The name derives from the limbs of afflicted animals being thin, elongated, and "spider-like".[8]

References

  1. ↑ Hereditary chondrodysplasia ("spider syndrome") in a New Zealand Suffolk lamb of American origin., originally published in New Zealand veterinary journal, Volume 43, p.118-22 (1995); by West, DM; Burbidge, H M; Vermunt, J J; Arthur, D G; archived at the International Sheep Research Centre; retrieved July 19, 2012
  2. ↑ Developmental progression of the Spider Lamb Syndrome in Small Ruminant Research, Volume 18, Issue 2 , Pages 179-184, October 1995, by A.M. Oberbauer, N.E. East, R. Pool, J.D. Rowe, and R.H. BonDurant
  3. 1 2 Spider Lamb Syndrome: Introduction at UC Davis School of Veterinary Medicine; retrieved July 19, 2012
  4. ↑ Spider Lamb Syndrome - 1998 Sheep Day Report: The Test for Spider Lamb Syndrome Gene in Sheep at North Dakota State University; by Bert Moore, Wes Limesand and Paul Berg; publisher 1998; retrieved July 19, 2012
  5. ↑ Spider Lamb Syndrome, at the Merck Veterinary Manual; published 2011; retrieved July 19, 2012
  6. ↑ Localization of the locus causing Spider Lamb Syndrome to the distal end of ovine Chromosome 6, from Mammalian Genome 10, 35–38 (1999); by N.E. Cockett,T.L. Shay, J.E. Beever, D. Nielsen, J. Albretsen, M. Georges, K. Peterson, A. Stephens, W. Vernon, O. Timofeevskaia, S. South, J. Mork, A. Maciulis, T.D. Bunch; archived at the University of Liège; retrieved July 19, 2012
  7. ↑ Enhanced skeletal growth of sheep heterozygous for an inactivated fibroblast growth factor receptor 3, Journal of Animal Science, vol. 84 no. 11 2942-2949; by L. B. Smith, M. R. Dally, R. D. Sainz, K. L. Rodrigue and A. M. Oberbauer
  8. ↑ A Novel Mutation in FGFR3 Causes Camptodactyly, Tall Stature, and Hearing Loss (CATSHL) Syndrome, Am J Hum Genet. 2006 November; 79(5): 935–941; published online 2006 September 26; by Reha M. Toydemir, Anna E. Brassington, Pınar Bayrak-Toydemir, Patrycja A. Krakowiak, Lynn B. Jorde, Frank G. Whitby, Nicola Longo, David H. Viskochil, John C. Carey, and Michael J. Bamshad
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