Oxoglutarate dehydrogenase (NADP+)

oxoglutarate dehydrogenase (NADP+)
Identifiers
EC number	1.2.1.52
CAS number	126469-85-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, an oxoglutarate dehydrogenase (NADP+) (EC 1.2.1.52) is an enzyme that catalyzes the chemical reaction

2-oxoglutarate + CoA + NADP⁺ $\rightleftharpoons$ succinyl-CoA + CO₂ + NADPH

The 3 substrates of this enzyme are 2-oxoglutarate, CoA, and NADP⁺, whereas its 3 products are succinyl-CoA, CO₂, and NADPH.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2-oxoglutarate:NADP+ 2-oxidoreductase (CoA-succinylating). This enzyme is also called oxoglutarate dehydrogenase (NADP+).

References

• Inui H, Miyatake K, Nakano Y, Kitaoka S. "Occurrence of oxygen-sensitive, NADP+-dependent pyruvate dehydrogenase in mitochondria of Euglena gracilis". J. (Tokyo). Biochem. (3): 931–4. PMID 6438078.