PACSIN3

Protein kinase C and casein kinase substrate in neurons 3
Identifiers
Symbols	PACSIN3 ; SDPIII
External IDs	OMIM: 606513 MGI: 1891410 HomoloGene: 41117 GeneCards: PACSIN3 Gene
Gene ontology Molecular function • protein binding • phospholipid binding • cytoskeletal protein binding • lipid binding • calcium channel inhibitor activity Cellular component • nucleoplasm • cytoplasm • endosome • plasma membrane • membrane-bounded vesicle • extracellular exosome Biological process • endocytosis • cytoskeleton organization • regulation of endocytosis • negative regulation of endocytosis • positive regulation of membrane protein ectodomain proteolysis • negative regulation of calcium ion transport • membrane tubulation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	29763	80708
Ensembl	ENSG00000165912	ENSMUSG00000027257
UniProt	Q9UKS6	Q99JB8
RefSeq (mRNA)	NM_001184974	NM_001289677
RefSeq (protein)	NP_001171903	NP_001276606
Location (UCSC)	Chr 11: 47.18 – 47.19 Mb	Chr 2: 91.26 – 91.26 Mb
PubMed search

Protein kinase C and casein kinase substrate in neurons protein 3 is an enzyme that in humans is encoded by the PACSIN3 gene.^[1][2]

Interactions

PACSIN3 has been shown to interact with PACSIN1^[3] and PACSIN2.^[3]

References

1. Howard L, Nelson KK, Maciewicz RA, Blobel CP (December 1999). "Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1". J Biol Chem 274 (44): 31693–9. doi:10.1074/jbc.274.44.31693. PMID 10531379.
2. "Entrez Gene: PACSIN3 protein kinase C and casein kinase substrate in neurons 3".
3. Modregger, J; Ritter B; Witter B; Paulsson M; Plomann M (December 2000). "All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis". J. Cell. Sci. 113 (ENGLAND). Pt 24: 4511–21. ISSN 0021-9533. PMID 11082044.

Further reading

• Modregger J, Ritter B, Witter B, et al. (2001). "All three PACSIN isoforms bind to endocytic proteins and inhibit endocytosis.". J. Cell. Sci. 113. Pt 24: 4511–21. PMID 11082044.
• Sumoy L, Pluvinet R, Andreu N, et al. (2001). "PACSIN 3 is a novel SH3 domain cytoplasmic adapter protein of the pacsin-syndapin-FAP52 gene family.". Gene 262 (1-2): 199–205. doi:10.1016/S0378-1119(00)00531-X. PMID 11179684.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mori S, Tanaka M, Nanba D, et al. (2003). "PACSIN3 binds ADAM12/meltrin alpha and up-regulates ectodomain shedding of heparin-binding epidermal growth factor-like growth factor.". J. Biol. Chem. 278 (46): 46029–34. doi:10.1074/jbc.M306393200. PMID 12952982.
• Schulze WX, Mann M (2004). "A novel proteomic screen for peptide-protein interactions.". J. Biol. Chem. 279 (11): 10756–64. doi:10.1074/jbc.M309909200. PMID 14679214.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Onodera Y, Hashimoto S, Hashimoto A, et al. (2005). "Expression of AMAP1, an ArfGAP, provides novel targets to inhibit breast cancer invasive activities.". EMBO J. 24 (5): 963–73. doi:10.1038/sj.emboj.7600588. PMC 554134. PMID 15719014.
• Cuajungco MP, Grimm C, Oshima K, et al. (2006). "PACSINs bind to the TRPV4 cation channel. PACSIN 3 modulates the subcellular localization of TRPV4.". J. Biol. Chem. 281 (27): 18753–62. doi:10.1074/jbc.M602452200. PMID 16627472.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.