PAG1

Phosphoprotein membrane anchor with glycosphingolipid microdomains 1
Identifiers
Symbols	PAG1 ; CBP; PAG
External IDs	OMIM: 605767 MGI: 2443160 HomoloGene: 10198 GeneCards: PAG1 Gene
Gene ontology Molecular function • SH3/SH2 adaptor activity • protein binding • SH2 domain binding Cellular component • intracellular • plasma membrane • integral component of membrane • membrane raft Biological process • adaptive immune response • signal transduction • epidermal growth factor receptor signaling pathway • positive regulation of signal transduction • intracellular signal transduction • T cell receptor signaling pathway • regulation of T cell activation • negative regulation of T cell activation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	55824	94212
Ensembl	ENSG00000076641	ENSMUSG00000027508
UniProt	Q9NWQ8	Q3U1F9
RefSeq (mRNA)	NM_018440	NM_001195031
RefSeq (protein)	NP_060910	NP_001181960
Location (UCSC)	Chr 8: 80.97 – 81.11 Mb	Chr 3: 9.69 – 9.83 Mb
PubMed search

Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 is a protein that in humans is encoded by the PAG1 gene.^[1][2]

The protein encoded by this gene is a type III transmembrane adaptor protein that binds to the tyrosine kinase csk protein. It is thought to be involved in the regulation of T cell activation.^[2]

Interactions

PAG1 has been shown to interact with FYN,^[1] C-src tyrosine kinase,^[1] Sodium-hydrogen antiporter 3 regulator 1^[3] and Abl gene.^[4]

References

1. Brdicka T, Pavlistova D, Leo A, Bruyns E, Korinek V, Angelisova P, Scherer J, Shevchenko A, Hilgert I, Cerny J, Drbal K, Kuramitsu Y, Kornacker B, Horejsi V, Schraven B (May 2000). "Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation". J Exp Med 191 (9): 1591–604. doi:10.1084/jem.191.9.1591. PMC 2213442. PMID 10790433.
2. "Entrez Gene: PAG1 phosphoprotein associated with glycosphingolipid microdomains 1".
3. Brdicková, N; Brdicka T; Andera L; Spicka J; Angelisová P; Milgram S L; Horejsí V (Oct 2001). "Interaction between two adapter proteins, PAG and EBP50: a possible link between membrane rafts and actin cytoskeleton". FEBS Lett. (Netherlands) 507 (2): 133–6. doi:10.1016/S0014-5793(01)02955-6. ISSN 0014-5793. PMID 11684085.
4. Wen, S T; Van Etten R A (Oct 1997). "The PAG gene product, a stress-induced protein with antioxidant properties, is an Abl SH3-binding protein and a physiological inhibitor of c-Abl tyrosine kinase activity". Genes Dev. (UNITED STATES) 11 (19): 2456–67. doi:10.1101/gad.11.19.2456. ISSN 0890-9369. PMC 316562. PMID 9334312.

Further reading

• Wen ST, Van Etten RA (1997). "The PAG gene product, a stress-induced protein with antioxidant properties, is an Abl SH3-binding protein and a physiological inhibitor of c-Abl tyrosine kinase activity.". Genes Dev. 11 (19): 2456–67. doi:10.1101/gad.11.19.2456. PMC 316562. PMID 9334312.
• Brdicková N, Brdicka T, Andera L, et al. (2001). "Interaction between two adapter proteins, PAG and EBP50: a possible link between membrane rafts and actin cytoskeleton.". FEBS Lett. 507 (2): 133–6. doi:10.1016/S0014-5793(01)02955-6. PMID 11684085.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Tedoldi S, Paterson JC, Hansmann ML, et al. (2006). "Transmembrane adaptor molecules: a new category of lymphoid-cell markers.". Blood 107 (1): 213–21. doi:10.1182/blood-2005-06-2273. PMID 16160011.
• Jiang LQ, Feng X, Zhou W, et al. (2006). "Csk-binding protein (Cbp) negatively regulates epidermal growth factor-induced cell transformation by controlling Src activation.". Oncogene 25 (40): 5495–506. doi:10.1038/sj.onc.1209554. PMID 16636672.
• Takeuchi S (2007). "Expression and purification of human PAG, a transmembrane adapter protein using an insect cell expression system and its structure basis.". Protein J. 25 (4): 295–9. doi:10.1007/s10930-006-9015-6. PMID 16947079.
• Roberts AE, Araki T, Swanson KD, et al. (2007). "Germline gain-of-function mutations in SOS1 cause Noonan syndrome.". Nat. Genet. 39 (1): 70–4. doi:10.1038/ng1926. PMID 17143285.
• Smida M, Posevitz-Fejfar A, Horejsi V, et al. (2007). "A novel negative regulatory function of the phosphoprotein associated with glycosphingolipid-enriched microdomains: blocking Ras activation.". Blood 110 (2): 596–615. doi:10.1182/blood-2006-07-038752. PMID 17389760.