PAIP1

Poly(A) binding protein interacting protein 1
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1JH4​, 3NTW​, 3RK6​
Identifiers
Symbols	PAIP1 ; MGC12360
External IDs	OMIM: 605184 MGI: 2384993 HomoloGene: 4709 GeneCards: PAIP1 Gene
Gene ontology Molecular function • RNA binding • protein binding • translation activator activity Cellular component • cytoplasm • cytosol Biological process • nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay • nuclear-transcribed mRNA poly(A) tail shortening • translational initiation • gene expression • positive regulation of translation • mRNA stabilization Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10605	218693
Ensembl	ENSG00000172239	ENSMUSG00000025451
UniProt	Q9H074	Q8VE62
RefSeq (mRNA)	NM_006451	NM_001079849
RefSeq (protein)	NP_006442	NP_001073318
Location (UCSC)	Chr 5: 43.53 – 43.56 Mb	Chr 13: 119.43 – 119.46 Mb
PubMed search

Polyadenylate-binding protein-interacting protein 1 is a protein that in humans is encoded by the PAIP1 gene.^[1][2][3]

Function

The protein encoded by this gene interacts with poly(A)-binding protein and with the cap-binding complex eIF4A. It is involved in translational initiation and protein biosynthesis. Overexpression of this gene in COS7 cells stimulates translation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.^[3]

Interactions

PAIP1 has been shown to interact with PABPC1.^[1][4]

References

1. Craig AW, Haghighat A, Yu AT, Sonenberg N (Apr 1998). "Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation". Nature 392 (6675): 520–3. doi:10.1038/33198. PMID 9548260.
2. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
3. "Entrez Gene: PAIP1 poly(A) binding protein interacting protein 1".
4. Roy G, De Crescenzo G, Khaleghpour K, Kahvejian A, O'Connor-McCourt M, Sonenberg N (Jun 2002). "Paip1 interacts with poly(A) binding protein through two independent binding motifs". Mol. Cell. Biol. 22 (11): 3769–82. doi:10.1128/MCB.22.11.3769-3782.2002. PMC 133836. PMID 11997512.

Further reading

• Gray NK, Coller JM, Dickson KS, Wickens M (2000). "Multiple portions of poly(A)-binding protein stimulate translation in vivo". EMBO J. 19 (17): 4723–33. doi:10.1093/emboj/19.17.4723. PMC 302064. PMID 10970864.
• Grosset C, Chen CY, Xu N, Sonenberg N, Jacquemin-Sablon H, Shyu AB (2000). "A mechanism for translationally coupled mRNA turnover: interaction between the poly(A) tail and a c-fos RNA coding determinant via a protein complex". Cell 103 (1): 29–40. doi:10.1016/S0092-8674(00)00102-1. PMID 11051545.
• Khaleghpour K, Svitkin YV, Craig AW, DeMaria CT, Deo RC, Burley SK, Sonenberg N (2001). "Translational repression by a novel partner of human poly(A) binding protein, Paip2". Mol. Cell 7 (1): 205–16. doi:10.1016/S1097-2765(01)00168-X. PMID 11172725.
• Deo RC, Sonenberg N, Burley SK (2001). "X-ray structure of the human hyperplastic discs protein: an ortholog of the C-terminal domain of poly(A)-binding protein". Proc. Natl. Acad. Sci. U.S.A. 98 (8): 4414–9. doi:10.1073/pnas.071552198. PMC 31849. PMID 11287654.
• Roy G, De Crescenzo G, Khaleghpour K, Kahvejian A, O'Connor-McCourt M, Sonenberg N (2002). "Paip1 interacts with poly(A) binding protein through two independent binding motifs". Mol. Cell. Biol. 22 (11): 3769–82. doi:10.1128/MCB.22.11.3769-3782.2002. PMC 133836. PMID 11997512.
• Fortna A, Kim Y, MacLaren E, Marshall K, Hahn G, Meltesen L, Brenton M, Hink R, Burgers S, Hernandez-Boussard T, Karimpour-Fard A, Glueck D, McGavran L, Berry R, Pollack J, Sikela JM (2004). "Lineage-specific gene duplication and loss in human and great ape evolution". PLoS Biol. 2 (7): E207. doi:10.1371/journal.pbio.0020207. PMC 449870. PMID 15252450.