PAK6

P21 protein (Cdc42/Rac)-activated kinase 6
PDB rendering based on 2c30.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2C30​, 2ODB​, 4KS7​, 4KS8​
Identifiers
Symbols	PAK6 ; PAK5
External IDs	OMIM: 608110 MGI: 2679420 HomoloGene: 23200 ChEMBL: 4311 GeneCards: PAK6 Gene
EC number	2.7.11.1
Gene ontology Molecular function • protein serine/threonine kinase activity • protein binding • ATP binding • Rac GTPase binding Cellular component • nucleus • cytoplasm Biological process • regulation of transcription, DNA-templated • apoptotic process • cytoskeleton organization • Rho protein signal transduction • regulation of mitotic cell cycle • cell migration • signal transduction by protein phosphorylation • actin cytoskeleton organization • stress-activated protein kinase signaling cascade • activation of protein kinase activity • regulation of apoptotic process • regulation of MAPK cascade Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	56924	214230
Ensembl	ENSG00000137843	ENSMUSG00000074923
UniProt	Q9NQU5	Q3ULB5
RefSeq (mRNA)	NM_001128628	NM_001033254
RefSeq (protein)	NP_001122100	NP_001028426
Location (UCSC)	Chr 15: 40.22 – 40.28 Mb	Chr 2: 118.66 – 118.7 Mb
PubMed search

Serine/threonine-protein kinase PAK 6 is an enzyme that in humans is encoded by the PAK6 gene.^[1][2]

This gene encodes a protein that shares a high degree of sequence similarity with p21-activated kinase (PAK) family members. The proteins of this family are Rac/Cdc42-associated Ste20-like Ser/Thr protein kinases, characterized by a highly conserved amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. PAK kinases are implicated in the regulation of a number of cellular processes, including cytoskeleton rearrangement, apoptosis and the MAP kinase signaling pathway. The protein encoded by this gene was found to interact with androgen receptor (AR), which is a steroid hormone-dependent transcription factor that is important for male sexual differentiation and development. The p21-activated protein kinase 6 gene was found to be highly expressed in testis and prostate tissues and the encoded protein was shown to cotranslocate into the nucleus with AR in response to androgen.^[2]

Interactions

PAK6 has been shown to interact with Androgen receptor.^[1][3]

References

1. Yang F, Li X, Sharma M, Zarnegar M, Lim B, Sun Z (Apr 2001). "Androgen receptor specifically interacts with a novel p21-activated kinase, PAK6". J Biol Chem 276 (18): 15345–53. doi:10.1074/jbc.M010311200. PMID 11278661.
2. "Entrez Gene: PAK6 p21(CDKN1A)-activated kinase 6".
3. Lee, Suzanne R; Ramos Sharon M; Ko Andrew; Masiello David; Swanson Kenneth D; Lu Michael L; Balk Steven P (Jan 2002). "AR and ER interaction with a p21-activated kinase (PAK6)". Mol. Endocrinol. (United States) 16 (1): 85–99. doi:10.1210/me.16.1.85. ISSN 0888-8809. PMID 11773441.

Further reading

• Lee SR, Ramos SM, Ko A, et al. (2002). "AR and ER interaction with a p21-activated kinase (PAK6).". Mol. Endocrinol. 16 (1): 85–99. doi:10.1210/me.16.1.85. PMID 11773441.
• Pandey A, Dan I, Kristiansen TZ, et al. (2002). "Cloning and characterization of PAK5, a novel member of mammalian p21-activated kinase-II subfamily that is predominantly expressed in brain.". Oncogene 21 (24): 3939–48. doi:10.1038/sj.onc.1205478. PMID 12032833.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ching YP, Leong VY, Wong CM, Kung HF (2003). "Identification of an autoinhibitory domain of p21-activated protein kinase 5.". J. Biol. Chem. 278 (36): 33621–4. doi:10.1074/jbc.C300234200. PMID 12860998.
• Schrantz N, da Silva Correia J, Fowler B, et al. (2004). "Mechanism of p21-activated kinase 6-mediated inhibition of androgen receptor signaling.". J. Biol. Chem. 279 (3): 1922–31. doi:10.1074/jbc.M311145200. PMID 14573606.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kaur R, Liu X, Gjoerup O, et al. (2005). "Activation of p21-activated kinase 6 by MAP kinase kinase 6 and p38 MAP kinase.". J. Biol. Chem. 280 (5): 3323–30. doi:10.1074/jbc.M406701200. PMID 15550393.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.