PARP10

Poly (ADP-ribose) polymerase family, member 10
PDB rendering based on 2dhx.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2DHX​, 3HKV​
Identifiers
Symbols	PARP10 ; ARTD10
External IDs	OMIM: 609564 HomoloGene: 53133 GeneCards: PARP10 Gene
EC number	2.4.2.30
Gene ontology Molecular function • NAD+ ADP-ribosyltransferase activity • protein binding • K63-linked polyubiquitin binding Cellular component • nucleus • nucleoplasm • nucleolus • cytoplasm • Golgi apparatus Biological process • protein ADP-ribosylation • negative regulation of gene expression • regulation of chromatin assembly • negative regulation of NF-kappaB transcription factor activity • negative regulation of protein import into nucleus, translocation • negative regulation of viral genome replication • negative regulation of fibroblast proliferation • protein poly-ADP-ribosylation • protein auto-ADP-ribosylation • negative regulation of protein K63-linked ubiquitination Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	84875	671535
Ensembl	ENSG00000178685	ENSMUSG00000063268
UniProt	Q53GL7	Q3U6C0
RefSeq (mRNA)	NM_032789	NM_001163575
RefSeq (protein)	NP_116178	NP_001157047
Location (UCSC)	Chr 8: 143.98 – 144.01 Mb	Chr 15: 76.23 – 76.24 Mb
PubMed search

Poly [ADP-ribose] polymerase 10 is an enzyme that in humans is encoded by the PARP10 gene.^[1][2]

Poly(ADP-ribose) polymerases (PARPs), such as PARP10, regulate gene transcription by altering chromatin organization by adding ADP-ribose to histones. PARPs can also function as transcriptional cofactors (Yu et al., 2005).[supplied by OMIM]^[2]

References

1. Ame JC, Spenlehauer C, de Murcia G (Jul 2004). "The PARP superfamily". BioEssays 26 (8): 882–93. doi:10.1002/bies.20085. PMID 15273990.
2. "Entrez Gene: PARP10 poly (ADP-ribose) polymerase family, member 10".

Further reading

• Chou HY, Chou HT, Lee SC (2006). "CDK-dependent activation of poly(ADP-ribose) polymerase member 10 (PARP10).". J. Biol. Chem. 281 (22): 15201–7. doi:10.1074/jbc.M506745200. PMID 16455663.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Yu M, Schreek S, Cerni C, et al. (2005). "PARP-10, a novel Myc-interacting protein with poly(ADP-ribose) polymerase activity, inhibits transformation.". Oncogene 24 (12): 1982–93. doi:10.1038/sj.onc.1208410. PMID 15674325.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.