PCBP4

Poly(rC) binding protein 4
Identifiers
Symbols PCBP4 ; CBP; LIP4; MCG10
External IDs OMIM: 608503 MGI: 1890471 HomoloGene: 56926 GeneCards: PCBP4 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 57060 59092
Ensembl ENSG00000090097 ENSMUSG00000023495
UniProt P57723 P57724
RefSeq (mRNA) NM_001174100 NM_021567
RefSeq (protein) NP_001167571 NP_067542
Location (UCSC) Chr 3:
51.96 – 51.97 Mb
Chr 9:
106.45 – 106.46 Mb
PubMed search

Poly(rC)-binding protein 4 is a protein that in humans is encoded by the PCBP4 gene.[1][2]

This gene encodes a member of the KH-domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. This gene is induced by the p53 tumor suppressor, and the encoded protein can suppress cell proliferation by inducing apoptosis and cell cycle arrest in G(2)-M. This gene's protein is found in the cytoplasm, yet it lacks the nuclear localization signals found in other subfamily members. Multiple alternatively spliced transcript variants have been described, but the full-length nature for only some has been determined.[2]

References

  1. Makeyev AV, Liebhaber SA (Sep 2000). "Identification of two novel mammalian genes establishes a subfamily of KH-domain RNA-binding proteins". Genomics 67 (3): 301–16. doi:10.1006/geno.2000.6244. PMID 10936052.
  2. 1 2 "Entrez Gene: PCBP4 poly(rC) binding protein 4".

Further reading

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