PCDH12

Protocadherin 12
Identifiers
Symbols	PCDH12 ; VE-cadherin-2; VECAD2
External IDs	OMIM: 605622 MGI: 1855700 HomoloGene: 9574 GeneCards: PCDH12 Gene
Gene ontology Molecular function • calcium ion binding Cellular component • plasma membrane • integral component of plasma membrane • cell-cell junction • extracellular exosome Biological process • glycogen metabolic process • homophilic cell adhesion via plasma membrane adhesion molecules • neuron recognition • calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules • labyrinthine layer development Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51294	53601
Ensembl	ENSG00000113555	ENSMUSG00000024440
UniProt	Q9NPG4	O55134
RefSeq (mRNA)	NM_016580	NM_017378
RefSeq (protein)	NP_057664	NP_059074
Location (UCSC)	Chr 5: 141.94 – 141.97 Mb	Chr 18: 38.27 – 38.28 Mb
PubMed search

Protocadherin-12 is a protein that in humans is encoded by the PCDH12 gene.^[1][2][3]

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein consists of an extracellular domain containing 6 cadherin repeats, a transmembrane domain and a cytoplasmic tail that differs from those of the classical cadherins. The gene localizes to the region on chromosome 5 where the protocadherin gene clusters reside. The exon organization of this transcript is similar to that of the gene cluster transcripts, notably the first large exon, but no significant sequence homology exists. The function of this cellular adhesion protein is undetermined but mouse protocadherin 12 does not bind catenins and appears to have no effect on cell migration or growth.^[3]

References

1. Wu Q, Maniatis T (Apr 2000). "Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes". Proc Natl Acad Sci U S A 97 (7): 3124–9. doi:10.1073/pnas.060027397. PMC 16203. PMID 10716726.
2. Wu Q, Maniatis T (Jul 1999). "A striking organization of a large family of human neural cadherin-like cell adhesion genes". Cell 97 (6): 779–90. doi:10.1016/S0092-8674(00)80789-8. PMID 10380929.
3. "Entrez Gene: PCDH12 protocadherin 12".

Further reading

• Yagi T, Takeichi M (2000). "Cadherin superfamily genes: functions, genomic organization, and neurologic diversity". Genes Dev. 14 (10): 1169–80. doi:10.1101/gad.14.10.1169. PMID 10817752.
• Nollet F, Kools P, van Roy F (2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members". J. Mol. Biol. 299 (3): 551–72. doi:10.1006/jmbi.2000.3777. PMID 10835267.
• Telo' P, Breviario F, Huber P, et al. (1998). "Identification of a novel cadherin (vascular endothelial cadherin-2) located at intercellular junctions in endothelial cells". J. Biol. Chem. 273 (28): 17565–72. doi:10.1074/jbc.273.28.17565. PMID 9651350.
• Ludwig D, Lorenz J, Dejana E, et al. (2001). "cDNA cloning, chromosomal mapping, and expression analysis of human VE-Cadherin-2". Mamm. Genome 11 (11): 1030–3. doi:10.1007/s003350010186. PMID 11063261.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.