PCDH7
| Protocadherin 7 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | PCDH7 ; BH-Pcdh; BHPCDH; PPP1R120 | ||||||||||||
| External IDs | OMIM: 602988 MGI: 1860487 HomoloGene: 36101 GeneCards: PCDH7 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 5099 | 54216 | |||||||||||
| Ensembl | ENSG00000169851 | ENSMUSG00000029108 | |||||||||||
| UniProt | O60245 | A2RS43 | |||||||||||
| RefSeq (mRNA) | NM_001173523 | NM_001122758 | |||||||||||
| RefSeq (protein) | NP_001166994 | NP_001116230 | |||||||||||
| Location (UCSC) |
Chr 4: 30.72 – 31.15 Mb |
Chr 5: 57.72 – 58.13 Mb | |||||||||||
| PubMed search | |||||||||||||
Protocadherin-7 is a protein that in humans is encoded by the PCDH7 gene.[1][2]
This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The gene encodes a protein with an extracellular domain containing 7 cadherin repeats. The gene product is an integral membrane protein that is thought to function in cell-cell recognition and adhesion. Alternative splicing yields isoforms with unique cytoplasmic tails.[2]
References
- ↑ Yoshida K, Yoshitomo-Nakagawa K, Seki N, Sasaki M, Sugano S (Aug 1998). "Cloning, expression analysis, and chromosomal localization of BH-protocadherin (PCDH7), a novel member of the cadherin superfamily". Genomics 49 (3): 458–61. doi:10.1006/geno.1998.5271. PMID 9615233.
- 1 2 "Entrez Gene: PCDH7 protocadherin 7".
Further reading
- Yagi T, Takeichi M (2000). "Cadherin superfamily genes: functions, genomic organization, and neurologic diversity.". Genes Dev. 14 (10): 1169–80. doi:10.1101/gad.14.10.1169. PMID 10817752.
- Nollet F, Kools P, van Roy F (2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.". J. Mol. Biol. 299 (3): 551–72. doi:10.1006/jmbi.2000.3777. PMID 10835267.
- Yoshida K, Watanabe M, Kato H, et al. (1999). "BH-protocadherin-c, a member of the cadherin superfamily, interacts with protein phosphatase 1 alpha through its intracellular domain.". FEBS Lett. 460 (1): 93–8. doi:10.1016/S0014-5793(99)01309-5. PMID 10571067.
- Wu Q, Maniatis T (2000). "Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3124–9. doi:10.1073/pnas.060027397. PMC 16203. PMID 10716726.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
- Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
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