PCGF6

Polycomb group ring finger 6
PDB rendering based on 2djb.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2DJB​
Identifiers
Symbols	PCGF6 ; MBLR; RNF134
External IDs	OMIM: 607816 MGI: 1918291 HomoloGene: 12378 GeneCards: PCGF6 Gene
Gene ontology Molecular function • RNA polymerase II regulatory region sequence-specific DNA binding • transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding • DNA binding • transcription factor activity, sequence-specific DNA binding • protein binding • zinc ion binding Cellular component • nucleus • PcG protein complex • PRC1 complex Biological process • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • negative regulation of transcription, DNA-templated Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	84108	71041
Ensembl	ENSG00000156374	ENSMUSG00000025050
UniProt	Q9BYE7	Q99NA9
RefSeq (mRNA)	NM_001011663	NM_027654
RefSeq (protein)	NP_001011663	NP_081930
Location (UCSC)	Chr 10: 103.3 – 103.35 Mb	Chr 19: 47.03 – 47.05 Mb
PubMed search

Polycomb group RING finger protein 6 is a protein that in humans is encoded by the PCGF6 gene.^[1][2]

The protein encoded by this gene contains a RING finger motif, which is most closely related to those of polycomb group (PcG) proteins RNF110/MEL-18 and BMI1. PcG proteins are known to form protein complexes and function as transcription repressors. This protein has been shown to interact with some PcG proteins and act as a transcription repressor. The activity of this protein is found to be regulated by cell cycle dependent phosphorylation. Alternatively spliced transcript variants encoding different isoforms have been identified.^[2]

References

1. Akasaka T, Takahashi N, Suzuki M, Koseki H, Bodmer R, Koga H (Aug 2002). "MBLR, a new RING finger protein resembling mammalian Polycomb gene products, is regulated by cell cycle-dependent phosphorylation". Genes Cells 7 (8): 835–50. doi:10.1046/j.1365-2443.2002.00565.x. PMID 12167161.
2. "Entrez Gene: PCGF6 polycomb group ring finger 6".

Further reading

• Kanno M, Hasegawa M, Ishida A, et al. (1996). "mel-18, a Polycomb group-related mammalian gene, encodes a transcriptional negative regulator with tumor suppressive activity.". EMBO J. 14 (22): 5672–8. PMC 394682. PMID 8521824.
• Trimarchi JM, Fairchild B, Wen J, Lees JA (2001). "The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex.". Proc. Natl. Acad. Sci. U.S.A. 98 (4): 1519–24. doi:10.1073/pnas.041597698. PMC 29289. PMID 11171983.
• Suzuki M, Mizutani-Koseki Y, Fujimura Y, et al. (2002). "Involvement of the Polycomb-group gene Ring1B in the specification of the anterior-posterior axis in mice.". Development 129 (18): 4171–83. PMID 12183370.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Zhong N, Radu G, Ju W, Brown WT (2006). "Novel progerin-interactive partner proteins hnRNP E1, EGF, Mel 18, and UBC9 interact with lamin A/C.". Biochem. Biophys. Res. Commun. 338 (2): 855–61. doi:10.1016/j.bbrc.2005.10.020. PMID 16248985.
• Lee MG, Norman J, Shilatifard A, Shiekhattar R (2007). "Physical and functional association of a trimethyl H3K4 demethylase and Ring6a/MBLR, a polycomb-like protein.". Cell 128 (5): 877–87. doi:10.1016/j.cell.2007.02.004. PMID 17320162.