PCOLCE2

Procollagen C-endopeptidase enhancer 2
Identifiers
Symbols	PCOLCE2 ; PCPE2
External IDs	OMIM: 607064 MGI: 1923727 HomoloGene: 8357 GeneCards: PCOLCE2 Gene
Gene ontology Molecular function • collagen binding • heparin binding • peptidase activator activity Cellular component • extracellular exosome Biological process • positive regulation of peptidase activity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	26577	76477
Ensembl	ENSG00000163710	ENSMUSG00000015354
UniProt	Q9UKZ9	Q8R4W6
RefSeq (mRNA)	NM_013363	NM_029620
RefSeq (protein)	NP_037495	NP_083896
Location (UCSC)	Chr 3: 142.82 – 142.89 Mb	Chr 9: 95.64 – 95.7 Mb
PubMed search

Procollagen C-endopeptidase enhancer 2 is an protein that in humans is encoded by the PCOLCE2 gene.^[1][2]

References

1. Xu H, Acott TS, Wirtz MK (Sep 2000). "Identification and expression of a novel type I procollagen C-proteinase enhancer protein gene from the glaucoma candidate region on 3q21-q24". Genomics 66 (3): 264–73. doi:10.1006/geno.2000.6229. PMID 10873381.
2. "Entrez Gene: PCOLCE2 procollagen C-endopeptidase enhancer 2".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Kumar S, Connor JR, Dodds RA, et al. (2001). "Identification and initial characterization of 5000 expressed sequenced tags (ESTs) each from adult human normal and osteoarthritic cartilage cDNA libraries.". Osteoarthr. Cartil. 9 (7): 641–53. doi:10.1053/joca.2001.0421. PMID 11597177.
• Steiglitz BM, Greenspan DS (2002). "Assignment of the mouse Pcolce2 gene, which encodes procollagen C-proteinase enhancer protein 2, to chromosome 9 and localization of PCOLCE2 to human chromosome 3q23.". Cytogenet. Cell Genet. 95 (3-4): 244–5. doi:10.1159/000059356. PMID 12063410.
• Steiglitz BM, Keene DR, Greenspan DS (2003). "PCOLCE2 encodes a functional procollagen C-proteinase enhancer (PCPE2) that is a collagen-binding protein differing in distribution of expression and post-translational modification from the previously described PCPE1.". J. Biol. Chem. 277 (51): 49820–30. doi:10.1074/jbc.M209891200. PMID 12393877.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.