PCP4

Purkinje cell protein 4
Identifiers
Symbols	PCP4 ; PEP-19
External IDs	OMIM: 601629 MGI: 97509 HomoloGene: 4519 GeneCards: PCP4 Gene
Gene ontology Molecular function • calmodulin binding Cellular component • nucleus • cytosol Biological process • central nervous system development Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5121	18546
Ensembl	ENSG00000183036	ENSMUSG00000090223
UniProt	P48539	P63054
RefSeq (mRNA)	NM_006198	NM_008791
RefSeq (protein)	NP_006189	NP_032817
Location (UCSC)	Chr 21: 39.87 – 39.93 Mb	Chr 16: 96.47 – 96.53 Mb
PubMed search

Purkinje cell protein 4 is a protein that in humans is encoded by the PCP4 gene.^[1][2][3] Also known as PEP-19, PCP4 is a 7.6 kDa protein with an IQ-motif that binds to calmodulin (CaM).^[4] PCP4 is abundant in Purkinje cells of the cerebellum, and plays an important role in synaptic plasticity.^[4][5]

Function

PCP4 knockout mice have been reported to exhibit impaired locomotor learning and markedly altered synaptic plasticity in cerebellar Purkinje neurons.^[4] PCP4 accelerates both the association and dissociation of calcium (Ca²⁺) with calmodulin (CaM), which is postulated to influence the activity of CaM-dependent enzymes, especially CaM kinase II (CaMK-II).^[4][6][7]

References

1. Chen H, Bouras C, Antonarakis SE (Jan 1997). "Cloning of the cDNA for a human homolog of the rat PEP-19 gene and mapping to chromosome 21q22.2-q22.3". Hum Genet 98 (6): 672–7. doi:10.1007/s004390050282. PMID 8931698.
2. Cabin DE, Gardiner K, Reeves RH (Dec 1996). "Molecular genetic characterization and comparative mapping of the human PCP4 gene". Somat Cell Mol Genet 22 (3): 167–75. doi:10.1007/BF02369907. PMID 8914602.
3. "Entrez Gene: PCP4 Purkinje cell protein 4".
4. Wei P, Blundon JA, Rong Y, Zakharenko SS, Morgan JI (2011). "Impaired locomotor learning and altered cerebellar synaptic plasticity in pep-19/PCP4-null mice". Mol. Cell. Biol. 31 (14): 2838–44. doi:10.1128/MCB.05208-11. PMC 3133400. PMID 21576365.
5. Sangameswaran L, Hempstead J, Morgan JI (1989). "Molecular cloning of a neuron-specific transcript and its regulation during normal and aberrant cerebellar development". Proc. Natl. Acad. Sci. U.S.A. 86 (14): 5651–5. doi:10.1073/pnas.86.14.5651. PMC 297682. PMID 2748608.
6. Putkey JA, Kleerekoper Q, Gaertner TR, Waxham MN (2004). "A new role for IQ motif proteins in regulating calmodulin function.". J. Biol. Chem. 278 (50): 49667–70. doi:10.1074/jbc.C300372200. PMID 14551202.
7. Kleerekoper QK, Putkey JA (2009). "PEP-19, an intrinsically disordered regulator of calmodulin signaling". J. Biol. Chem. 284 (12): 7455–64. doi:10.1074/jbc.M808067200. PMC 2658041. PMID 19106096.

Further reading

• Hubert RS, Korenberg JR (1997). "PCP4 maps between D21S345 and P31P10SP6 on chromosome 21q22.2→q22.3.". Cytogenet. Cell Genet. 78 (1): 44–5. doi:10.1159/000134623. PMID 9345904.
• Utal AK, Stopka AL, Roy M, Coleman PD (1998). "PEP-19 immunohistochemistry defines the basal ganglia and associated structures in the adult human brain, and is dramatically reduced in Huntington's disease.". Neuroscience 86 (4): 1055–63. doi:10.1016/S0306-4522(98)00130-4. PMID 9697113.
• Hu YH, Warnatz HJ, Vanhecke D, Wagner F, Fiebitz A, Thamm S, Kahlem P, Lehrach H, Yaspo ML, Janitz M (2006). "Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins.". BMC Genomics 7: 155. doi:10.1186/1471-2164-7-155. PMC 1526728. PMID 16780588.