PDCD4

Programmed cell death 4 (neoplastic transformation inhibitor)
PDB rendering based on 2ggf.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2GGF​, 2KZT​, 2RG8​, 2ZU6​, 3EIJ​
Identifiers
Symbols	PDCD4 ; H731
External IDs	OMIM: 608610 MGI: 107490 HomoloGene: 7879 ChEMBL: 1781868 GeneCards: PDCD4 Gene
Gene ontology Molecular function • RNA binding • protein binding Cellular component • nucleus • nucleoplasm • cytoplasm • cytosol Biological process • apoptotic process • cell aging • positive regulation of smooth muscle cell apoptotic process • negative regulation of apoptotic process • negative regulation of JUN kinase activity • negative regulation of cell cycle • negative regulation of transcription, DNA-templated Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	27250	18569
Ensembl	ENSG00000150593	ENSMUSG00000024975
UniProt	Q53EL6	Q61823
RefSeq (mRNA)	NM_001199492	NM_001168491
RefSeq (protein)	NP_001186421	NP_001161963
Location (UCSC)	Chr 10: 110.87 – 110.9 Mb	Chr 19: 53.89 – 53.93 Mb
PubMed search

Programmed cell death protein 4 is a protein that in humans is encoded by the PDCD4 gene.^[1][2] It is one of the targets of an oncomiR, MIRN21.^[3]

Function

This gene encodes a protein localized to the nucleus in proliferating cells. Expression of this gene is modulated by cytokines in natural killer and T cells. The gene product is thought to play a role in apoptosis but the specific role has not yet been determined. Two transcripts encoding different isoforms have been identified.^[2]

Interactions

PDCD4 has been shown to interact with RPS13^[4] and Ribosomal protein L5.^[4]

References

1. Azzoni L, Zatsepina O, Abebe B, Bennett IM, Kanakaraj P, Perussia B (1998). "Differential transcriptional regulation of CD161 and a novel gene, 197/15a, by IL-2, IL-15, and IL-12 in NK and T cells". Journal of immunology 161 (7): 3493–500. PMID 9759869.
2. EntrezGene 27250
3. Frankel LB, Christoffersen NR, Jacobsen A, Lindow M, Krogh A, Lund AH (2008). "Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells". The Journal of Biological Chemistry 283 (2): 1026–33. doi:10.1074/jbc.M707224200. PMID 17991735.
4. Kang MJ, Ahn HS, Lee JY, Matsuhashi S, Park WY (2002). "Up-regulation of PDCD4 in senescent human diploid fibroblasts". Biochemical and Biophysical Research Communications 293 (1): 617–21. doi:10.1016/S0006-291X(02)00264-4. PMID 12054647.

Further reading

• Göke R, Gregel C, Göke A, Arnold R, Schmidt H, Lankat-Buttgereit B (2004). "Programmed Cell Death Protein 4 (PDCD4) Acts As a Tumor Suppressor in Neuroendocrine Tumor Cells". Annals of the New York Academy of Sciences 1014: 220–1. doi:10.1196/annals.1294.024. PMID 15153438.
• Maruyama K, Sugano S (1994). "Oligo-capping: A simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Shibahara K, Asano M, Ishida Y, Aoki T, Koike T, Honjo T (1995). "Isolation of a novel mouse gene MA-3 that is induced upon programmed cell death". Gene 166 (2): 297–301. doi:10.1016/0378-1119(95)00607-9. PMID 8543179.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5′-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Yoshinaga H, Matsuhashi S, Fujiyama C, Masaki Z (1999). "Novel human PDCD4 (H731) gene expressed in proliferative cells is expressed in the small duct epithelial cells of the breast as revealed by an anti-H731 antibody". Pathology International 49 (12): 1067–77. doi:10.1046/j.1440-1827.1999.00995.x. PMID 10632927.
• Soejima, H.; Miyoshi, O.; Yoshinaga, H.; Masaki, Z.; Ozaki, I.; Kajiwara, S.; Niikawa, N.; Matsuhashi, S.; Mukai, T. (1999). "Assignment¹ of the programmed cell death 4 gene (PDCD4) to human chromosome band 10q24 by in situ hybridization". Cytogenetic and Genome Research 87: 113–4. doi:10.1159/000015408.
• Kang MJ, Ahn HS, Lee JY, Matsuhashi S, Park WY (2002). "Up-regulation of PDCD4 in senescent human diploid fibroblasts". Biochemical and Biophysical Research Communications 293 (1): 617–21. doi:10.1016/S0006-291X(02)00264-4. PMID 12054647.
• Chen Y, Knösel T, Kristiansen G, Pietas A, Garber ME, Matsuhashi S, Ozaki I, Petersen I (2003). "Loss of PDCD4 expression in human lung cancer correlates with tumour progression and prognosis". The Journal of Pathology 200 (5): 640–6. doi:10.1002/path.1378. PMID 12898601.
• Yang HS, Cho MH, Zakowicz H, Hegamyer G, Sonenberg N, Colburn NH (2004). "A Novel Function of the MA-3 Domains in Transformation and Translation Suppressor Pdcd4 is Essential for Its Binding to Eukaryotic Translation Initiation Factor 4A". Molecular and Cellular Biology 24 (9): 3894–906. doi:10.1128/MCB.24.9.3894-3906.2004. PMC 387765. PMID 15082783.
• Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (2004). "Robust Phosphoproteomic Profiling of Tyrosine Phosphorylation Sites from Human T Cells Using Immobilized Metal Affinity Chromatography and Tandem Mass Spectrometry". Analytical Chemistry 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
• Göke R, Barth P, Schmidt A, Samans B, Lankat-Buttgereit B (2004). "Programmed cell death protein 4 suppresses CDK1/cdc2 via induction of p21Waf1/Cip1". AJP: Cell Physiology 287 (6): C1541–6. doi:10.1152/ajpcell.00025.2004. PMID 15317660.
• Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ (2004). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nature Biotechnology 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, et al. (2005). "Towards a proteome-scale map of the human protein–protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Palamarchuk A, Efanov A, Maximov V, Aqeilan RI, Croce CM, Pekarsky Y (2005). "Akt Phosphorylates and Regulates Pdcd4 Tumor Suppressor Protein". Cancer Research 65 (24): 11282–6. doi:10.1158/0008-5472.CAN-05-3469. PMID 16357133.
• Yang HS, Matthews CP, Clair T, Wang Q, Baker AR, Li CC, Tan TH, Colburn NH (2006). "Tumorigenesis Suppressor Pdcd4 Down-Regulates Mitogen-Activated Protein Kinase Kinase Kinase Kinase 1 Expression to Suppress Colon Carcinoma Cell Invasion". Molecular and Cellular Biology 26 (4): 1297–306. doi:10.1128/MCB.26.4.1297-1306.2006. PMC 1367180. PMID 16449643.