PDE1B

Phosphodiesterase 1B, calmodulin-dependent
PDB rendering based on 1taz.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1LXR​, 1TAZ​, 4NPV​, 4NPW​
Identifiers
Symbols	PDE1B ; HEL-S-79p; PDE1B1; PDES1B
External IDs	OMIM: 171891 MGI: 97523 HomoloGene: 37370 IUPHAR: 1295 ChEMBL: 4425 GeneCards: PDE1B Gene
EC number	3.1.4.17
Gene ontology Molecular function • 3',5'-cyclic-AMP phosphodiesterase activity • calmodulin-dependent cyclic-nucleotide phosphodiesterase activity • calmodulin binding • metal ion binding • calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity Cellular component • cytosol • neuronal cell body Biological process • regulation of neurotransmitter levels • response to amphetamine • cAMP catabolic process • apoptotic process • signal transduction • epidermal growth factor receptor signaling pathway • activation of phospholipase C activity • blood coagulation • locomotory behavior • visual learning • fibroblast growth factor receptor signaling pathway • monocyte differentiation • cellular response to macrophage colony-stimulating factor stimulus • regulation of dopamine metabolic process • serotonin metabolic process • innate immune response • cGMP catabolic process • neurotrophin TRK receptor signaling pathway • cellular response to granulocyte macrophage colony-stimulating factor stimulus Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5153	18574
Ensembl	ENSG00000123360	ENSMUSG00000022489
UniProt	Q01064	Q01065
RefSeq (mRNA)	NM_000924	NM_001285890
RefSeq (protein)	NP_000915	NP_001272819
Location (UCSC)	Chr 12: 54.55 – 54.58 Mb	Chr 15: 103.5 – 103.53 Mb
PubMed search

Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B is an enzyme that in humans is encoded by the PDE1B gene.^[1][2][3]

References

1. Jiang X, Li J, Paskind M, Epstein PM (Nov 1996). "Inhibition of calmodulin-dependent phosphodiesterase induces apoptosis in human leukemic cells". Proc Natl Acad Sci U S A 93 (20): 11236–41. doi:10.1073/pnas.93.20.11236. PMC 1074519. PMID 8855339.
2. Yu J, Wolda SL, Frazier AL, Florio VA, Martins TJ, Snyder PB, Harris EA, McCaw KN, Farrell CA, Steiner B, Bentley JK, Beavo JA, Ferguson K, Gelinas R (Feb 1998). "Identification and characterisation of a human calmodulin-stimulated phosphodiesterase PDE1B1". Cell Signal 9 (7): 519–29. doi:10.1016/S0898-6568(97)00046-6. PMID 9419816.
3. "Entrez Gene: PDE1B phosphodiesterase 1B, calmodulin-dependent".

Further reading

• Repaske DR, Swinnen JV, Jin SL, et al. (1992). "A polymerase chain reaction strategy to identify and clone cyclic nucleotide phosphodiesterase cDNAs. Molecular cloning of the cDNA encoding the 63-kDa calmodulin-dependent phosphodiesterase". J. Biol. Chem. 267 (26): 18683–8. PMID 1326532.
• Spence S, Rena G, Sullivan M, et al. (1997). "Receptor-mediated stimulation of lipid signalling pathways in CHO cells elicits the rapid transient induction of the PDE1B isoform of Ca2+/calmodulin-stimulated cAMP phosphodiesterase". Biochem. J. 321 ( Pt 1) (Pt 1): 157–63. PMC 1218050. PMID 9003415.
• Zauli G, Milani D, Mirandola P, et al. (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway". FASEB J. 15 (2): 483–91. doi:10.1096/fj.00-0354com. PMID 11156964.
• Fidock M, Miller M, Lanfear J (2002). "Isolation and differential tissue distribution of two human cDNAs encoding PDE1 splice variants". Cell. Signal. 14 (1): 53–60. doi:10.1016/S0898-6568(01)00207-8. PMID 11747989.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell Proteomics 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Bender AT, Ostenson CL, Wang EH, Beavo JA (2005). "Selective up-regulation of PDE1B2 upon monocyte-to-macrophage differentiation". Proc. Natl. Acad. Sci. U.S.A. 102 (2): 497–502. doi:10.1073/pnas.0408535102. PMC 544304. PMID 15625104.
• Bender AT, Beavo JA (2006). "PDE1B2 regulates cGMP and a subset of the phenotypic characteristics acquired upon macrophage differentiation from a monocyte". Proc. Natl. Acad. Sci. U.S.A. 103 (2): 460–5. doi:10.1073/pnas.0509972102. PMC 1326187. PMID 16407168.