PDE1C

Phosphodiesterase 1C, calmodulin-dependent 70kDa
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1LXS​
Identifiers
Symbols	PDE1C ; Hcam3; cam-PDE 1C; hCam-3
External IDs	OMIM: 602987 MGI: 108413 HomoloGene: 3682 ChEMBL: 4619 GeneCards: PDE1C Gene
EC number	3.1.4.17
Gene ontology Molecular function • calmodulin-dependent cyclic-nucleotide phosphodiesterase activity • calmodulin binding • metal ion binding Cellular component • cytosol Biological process • signal transduction • epidermal growth factor receptor signaling pathway • activation of phospholipase C activity • metabolic process • fibroblast growth factor receptor signaling pathway • innate immune response • neurotrophin TRK receptor signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5137	18575
Ensembl	ENSG00000154678	ENSMUSG00000004347
UniProt	Q14123	Q64338
RefSeq (mRNA)	NM_001191056	NM_001025568
RefSeq (protein)	NP_001177985	NP_001020739
Location (UCSC)	Chr 7: 31.75 – 32.3 Mb	Chr 6: 56.07 – 56.37 Mb
PubMed search

Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C is an enzyme that in humans is encoded by the PDE1C gene.^[1][2]

References

1. Loughney K, Martins TJ, Harris EA, Sadhu K, Hicks JB, Sonnenburg WK, Beavo JA, Ferguson K (Feb 1996). "Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases". J Biol Chem 271 (2): 796–806. doi:10.1074/jbc.271.2.796. PMID 8557689.
2. "Entrez Gene: PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa".

Further reading

• Vandeput F, Wolda SL, Krall J, et al. (2007). "Cyclic nucleotide phosphodiesterase PDE1C1 in human cardiac myocytes.". J. Biol. Chem. 282 (45): 32749–57. doi:10.1074/jbc.M703173200. PMID 17726023.
• Dolci S, Belmonte A, Santone R, et al. (2006). "Subcellular localization and regulation of type-1C and type-5 phosphodiesterases.". Biochem. Biophys. Res. Commun. 341 (3): 837–46. doi:10.1016/j.bbrc.2006.01.035. PMID 16455054.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Rybalkin SD, Rybalkina I, Beavo JA, Bornfeldt KE (2002). "Cyclic nucleotide phosphodiesterase 1C promotes human arterial smooth muscle cell proliferation.". Circ. Res. 90 (2): 151–7. doi:10.1161/hh0202.104108. PMID 11834707.
• Yan C, Zhao AZ, Sonnenburg WK, Beavo JA (2001). "Stage and cell-specific expression of calmodulin-dependent phosphodiesterases in mouse testis.". Biol. Reprod. 64 (6): 1746–54. doi:10.1095/biolreprod64.6.1746. PMID 11369604.
• Zauli G, Milani D, Mirandola P, et al. (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway.". FASEB J. 15 (2): 483–91. doi:10.1096/fj.00-0354com. PMID 11156964.