PDE2A

Phosphodiesterase 2A, cGMP-stimulated
PDB rendering based on 1mc0.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1Z1L​, 3IBJ​, 3ITM​, 3ITU​, 4C1I​, 4D08​, 4D09​, 4HTX​, 4HTZ​, 4JIB​
Identifiers
Symbols	PDE2A ; CGS-PDE; PDE2A1; PED2A4; cGSPDE
External IDs	OMIM: 602658 MGI: 2446107 HomoloGene: 1952 ChEMBL: 2652 GeneCards: PDE2A Gene
EC number	3.1.4.17
Gene ontology Molecular function • cyclic-nucleotide phosphodiesterase activity • cGMP-stimulated cyclic-nucleotide phosphodiesterase activity • calcium channel activity • protein binding • drug binding • cAMP binding • cGMP binding • TPR domain binding • protein homodimerization activity • metal ion binding Cellular component • nucleus • cytoplasm • mitochondrial matrix • endoplasmic reticulum • Golgi apparatus • cytosol • plasma membrane • presynaptic membrane • membrane raft • perinuclear region of cytoplasm Biological process • negative regulation of transcription from RNA polymerase II promoter • cAMP catabolic process • protein targeting to mitochondrion • blood coagulation • metabolic process • cAMP-mediated signaling • cGMP-mediated signaling • monocyte differentiation • negative regulation of cAMP biosynthetic process • negative regulation of protein import into nucleus, translocation • cellular response to drug • cellular response to macrophage colony-stimulating factor stimulus • negative regulation of vascular permeability • positive regulation of vascular permeability • cGMP catabolic process • positive regulation of inflammatory response • establishment of endothelial barrier • calcium ion transmembrane transport • cellular response to mechanical stimulus • cellular response to cGMP • cellular response to transforming growth factor beta stimulus • cellular response to granulocyte macrophage colony-stimulating factor stimulus Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5138	207728
Ensembl	ENSG00000186642	ENSMUSG00000030653
UniProt	O00408	Q922S4
RefSeq (mRNA)	NM_001143839	NM_001008548
RefSeq (protein)	NP_001137311	NP_001008548
Location (UCSC)	Chr 11: 72.58 – 72.67 Mb	Chr 7: 101.42 – 101.51 Mb
PubMed search

cGMP-dependent 3',5'-cyclic phosphodiesterase is an enzyme that in humans is encoded by the PDE2A gene.^[1][2]

References

1. Rosman GJ, Martins TJ, Sonnenburg WK, Beavo JA, Ferguson K, Loughney K (Aug 1997). "Isolation and characterization of human cDNAs encoding a cGMP-stimulated 3',5'-cyclic nucleotide phosphodiesterase". Gene 191 (1): 89–95. doi:10.1016/S0378-1119(97)00046-2. PMID 9210593.
2. "Entrez Gene: PDE2A phosphodiesterase 2A, cGMP-stimulated".

Further reading

• Witzenrath M, Gutbier B, Schmeck B, et al. (2005). "Phosphodiesterase 2 inhibition diminished acute lung injury in murine pneumococcal pneumonia". Critical Care Medicine 105 (9): 584–590. doi:10.1097/CCM.0b013e3181959814. PMID 19114892.
• Seybold J, Thomas D, Witzenrath M, et al. (2009). "Tumor necrosis factor-alpha-dependent expression of phosphodiesterase 2: role in endothelial hyperpermeability". Blood 105 (9): 3569–3576. doi:10.1182/blood-2004-07-2729. PMID 15650061.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Martinez SE, Wu AY, Glavas NA, et al. (2002). "The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding". Proc. Natl. Acad. Sci. U.S.A. 99 (20): 13260–13265. doi:10.1073/pnas.192374899. PMC 130621. PMID 12271124.
• Manns JM, Brenna KJ, Colman RW, Sheth SB (2002). "Differential regulation of human platelet responses by cGMP inhibited and stimulated cAMP phosphodiesterases". Thromb. Haemost. 87 (5): 873–9. PMID 12038792.
• Zauli G, Milani D, Mirandola P, et al. (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway". FASEB J. 15 (2): 483–491. doi:10.1096/fj.00-0354com. PMID 11156964.
• Sadhu K, Hensley K, Florio VA, Wolda SL (1999). "Differential expression of the cyclic GMP-stimulated phosphodiesterase PDE2A in human venous and capillary endothelial cells". J. Histochem. Cytochem. 47 (7): 895–906. doi:10.1177/002215549904700707. PMID 10375378.