PDE6D

Phosphodiesterase 6D, cGMP-specific, rod, delta

PDB rendering based on 1ksg.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PDE6D ; JBTS22; PDED
External IDs OMIM: 602676 MGI: 1270843 HomoloGene: 1954 ChEMBL: 3860 GeneCards: PDE6D Gene
EC number 3.1.4.17
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 5147 18582
Ensembl ENSG00000156973 ENSMUSG00000026239
UniProt O43924 O55057
RefSeq (mRNA) NM_001291018 NM_008801
RefSeq (protein) NP_001277947 NP_032827
Location (UCSC) Chr 2:
231.73 – 231.79 Mb		 Chr 1:
86.54 – 86.58 Mb
PubMed search

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta is an enzyme that in humans is encoded by the PDE6D gene.[1][2][3]

Interactions

PDE6D has been shown to interact with:

References

  1. ↑ Ershova G, Derré J, Chételin S, Nancy V, Berger R, Kaplan J, Munnich A, de Gunzburg J (Apr 1998). "cDNA sequence, genomic organization and mapping of PDE6D, the human gene encoding the delta subunit of the cGMP phosphodiesterase of retinal rod cells to chromosome 2q36". Cytogenetics and Cell Genetics 79 (1-2): 139–41. doi:10.1159/000134701. PMID 9533031.
  2. ↑ Li N, Florio SK, Pettenati MJ, Rao PN, Beavo JA, Baehr W (Apr 1998). "Characterization of human and mouse rod cGMP phosphodiesterase delta subunit (PDE6D) and chromosomal localization of the human gene". Genomics 49 (1): 76–82. doi:10.1006/geno.1998.5210. PMID 9570951.
  3. ↑ "Entrez Gene: PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta".
  4. ↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  5. 1 2 3 4 Hanzal-Bayer M, Renault L, Roversi P, Wittinghofer A, Hillig RC (May 2002). "The complex of Arl2-GTP and PDE delta: from structure to function". The EMBO Journal 21 (9): 2095–106. doi:10.1093/emboj/21.9.2095. PMC 125981. PMID 11980706.
  6. 1 2 3 Nancy V, Callebaut I, El Marjou A, de Gunzburg J (Apr 2002). "The delta subunit of retinal rod cGMP phosphodiesterase regulates the membrane association of Ras and Rap GTPases". The Journal of Biological Chemistry 277 (17): 15076–84. doi:10.1074/jbc.M109983200. PMID 11786539.
  7. ↑ Linari M, Ueffing M, Manson F, Wright A, Meitinger T, Becker J (Feb 1999). "The retinitis pigmentosa GTPase regulator, RPGR, interacts with the delta subunit of rod cyclic GMP phosphodiesterase". Proceedings of the National Academy of Sciences of the United States of America 96 (4): 1315–20. PMC 15460. PMID 9990021.

Further reading

  • Marzesco AM, Galli T, Louvard D, Zahraoui A (Aug 1998). "The rod cGMP phosphodiesterase delta subunit dissociates the small GTPase Rab13 from membranes". The Journal of Biological Chemistry 273 (35): 22340–5. doi:10.1074/jbc.273.35.22340. PMID 9712853. 
  • Lorenz B, Migliaccio C, Lichtner P, Meyer C, Strom TM, D'Urso M, Becker J, Ciccodicola A, Meitinger T (1998). "Cloning and gene structure of the rod cGMP phosphodiesterase delta subunit gene (PDED) in man and mouse". European Journal of Human Genetics 6 (3): 283–90. doi:10.1038/sj.ejhg.5200215. PMID 9781033. 
  • Linari M, Ueffing M, Manson F, Wright A, Meitinger T, Becker J (Feb 1999). "The retinitis pigmentosa GTPase regulator, RPGR, interacts with the delta subunit of rod cyclic GMP phosphodiesterase". Proceedings of the National Academy of Sciences of the United States of America 96 (4): 1315–20. doi:10.1073/pnas.96.4.1315. PMC 15460. PMID 9990021. 
  • Mou H, Grazio HJ, Cook TA, Beavo JA, Cote RH (Jun 1999). "cGMP binding to noncatalytic sites on mammalian rod photoreceptor phosphodiesterase is regulated by binding of its gamma and delta subunits". The Journal of Biological Chemistry 274 (26): 18813–20. doi:10.1074/jbc.274.26.18813. PMID 10373499. 
  • Linari M, Hanzal-Bayer M, Becker J (Sep 1999). "The delta subunit of rod specific cyclic GMP phosphodiesterase, PDE delta, interacts with the Arf-like protein Arl3 in a GTP specific manner". FEBS Letters 458 (1): 55–9. doi:10.1016/S0014-5793(99)01117-5. PMID 10518933. 
  • Nancy V, Callebaut I, El Marjou A, de Gunzburg J (Apr 2002). "The delta subunit of retinal rod cGMP phosphodiesterase regulates the membrane association of Ras and Rap GTPases". The Journal of Biological Chemistry 277 (17): 15076–84. doi:10.1074/jbc.M109983200. PMID 11786539. 
  • Hanzal-Bayer M, Renault L, Roversi P, Wittinghofer A, Hillig RC (May 2002). "The complex of Arl2-GTP and PDE delta: from structure to function". The EMBO Journal 21 (9): 2095–106. doi:10.1093/emboj/21.9.2095. PMC 125981. PMID 11980706. 
  • Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070. 
  • Wilson SJ, Smyth EM (Apr 2006). "Internalization and recycling of the human prostacyclin receptor is modulated through its isoprenylation-dependent interaction with the delta subunit of cGMP phosphodiesterase 6". The Journal of Biological Chemistry 281 (17): 11780–6. doi:10.1074/jbc.M513110200. PMID 16527812. 
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