PDE6G

Phosphodiesterase 6G, cGMP-specific, rod, gamma

PDB rendering based on 1fqj.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PDE6G ; PDEG; RP57
External IDs OMIM: 180073 MGI: 97526 HomoloGene: 1955 IUPHAR: 1316 ChEMBL: 2415 GeneCards: PDE6G Gene
EC number 3.1.4.35
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 5148 18588
Ensembl ENSG00000185527 ENSMUSG00000025386
UniProt P18545 P09174
RefSeq (mRNA) NM_002602 NM_012065
RefSeq (protein) NP_002593 NP_036197
Location (UCSC) Chr 17:
81.65 – 81.66 Mb
Chr 11:
120.45 – 120.45 Mb
PubMed search

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma is an enzyme that in humans is encoded by the PDE6G gene.[1][2]

Interactions

PDE6G has been shown to interact with Beta adrenergic receptor kinase[3] and Src.[3]

References

  1. Pittler SJ, Baehr W, Wasmuth JJ, McConnell DG, Champagne MS, vanTuinen P, Ledbetter D, Davis RL (Apr 1990). "Molecular characterization of human and bovine rod photoreceptor cGMP phosphodiesterase alpha-subunit and chromosomal localization of the human gene". Genomics 6 (2): 272–83. doi:10.1016/0888-7543(90)90567-E. PMID 2155175.
  2. "Entrez Gene: PDE6G phosphodiesterase 6G, cGMP-specific, rod, gamma".
  3. 1 2 Wan, Kah Fei; Sambi Balwinder S; Tate Rothwelle; Waters Catherine; Pyne Nigel J (May 2003). "The inhibitory gamma subunit of the type 6 retinal cGMP phosphodiesterase functions to link c-Src and G-protein-coupled receptor kinase 2 in a signaling unit that regulates p42/p44 mitogen-activated protein kinase by epidermal growth factor". J. Biol. Chem. (United States) 278 (20): 18658–63. doi:10.1074/jbc.M212103200. ISSN 0021-9258. PMID 12624098.

Further reading

External links

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