PDE6G

Phosphodiesterase 6G, cGMP-specific, rod, gamma
PDB rendering based on 1fqj.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3JWR​
Identifiers
Symbols	PDE6G ; PDEG; RP57
External IDs	OMIM: 180073 MGI: 97526 HomoloGene: 1955 IUPHAR: 1316 ChEMBL: 2415 GeneCards: PDE6G Gene
EC number	3.1.4.35
Gene ontology Molecular function • enzyme inhibitor activity • protein binding • spectrin binding • cGMP binding • 3',5'-cyclic-GMP phosphodiesterase activity Cellular component • plasma membrane • photoreceptor disc membrane Biological process • activation of MAPK activity • visual perception • phototransduction, visible light • metabolic process • rhodopsin mediated signaling pathway • regulation of rhodopsin mediated signaling pathway • negative regulation of catalytic activity • positive regulation of epidermal growth factor receptor signaling pathway • positive regulation of G-protein coupled receptor protein signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5148	18588
Ensembl	ENSG00000185527	ENSMUSG00000025386
UniProt	P18545	P09174
RefSeq (mRNA)	NM_002602	NM_012065
RefSeq (protein)	NP_002593	NP_036197
Location (UCSC)	Chr 17: 81.65 – 81.66 Mb	Chr 11: 120.45 – 120.45 Mb
PubMed search

Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma is an enzyme that in humans is encoded by the PDE6G gene.^[1][2]

Interactions

PDE6G has been shown to interact with Beta adrenergic receptor kinase^[3] and Src.^[3]

References

1. Pittler SJ, Baehr W, Wasmuth JJ, McConnell DG, Champagne MS, vanTuinen P, Ledbetter D, Davis RL (Apr 1990). "Molecular characterization of human and bovine rod photoreceptor cGMP phosphodiesterase alpha-subunit and chromosomal localization of the human gene". Genomics 6 (2): 272–83. doi:10.1016/0888-7543(90)90567-E. PMID 2155175.
2. "Entrez Gene: PDE6G phosphodiesterase 6G, cGMP-specific, rod, gamma".
3. Wan, Kah Fei; Sambi Balwinder S; Tate Rothwelle; Waters Catherine; Pyne Nigel J (May 2003). "The inhibitory gamma subunit of the type 6 retinal cGMP phosphodiesterase functions to link c-Src and G-protein-coupled receptor kinase 2 in a signaling unit that regulates p42/p44 mitogen-activated protein kinase by epidermal growth factor". J. Biol. Chem. (United States) 278 (20): 18658–63. doi:10.1074/jbc.M212103200. ISSN 0021-9258. PMID 12624098.

Further reading

• Cotran PR, Bruns GA, Berson EL, Dryja TP (1992). "Genetic analysis of patients with retinitis pigmentosa using a cloned cDNA probe for the human gamma subunit of cyclic GMP phosphodiesterase.". Exp. Eye Res. 53 (5): 557–64. doi:10.1016/0014-4835(91)90213-X. PMID 1683837.
• Piriev, N. I.; V. A. Purishko; N. V. Khramtsov; V. M. Lipkin (1991). "The organization of the gamma-subunit gene of human photoreceptor cyclic GMP phosphodiesterase" [The organization of the gamma-subunit gene of human photoreceptor cyclic GMP phosphodiesterase]. Doklady Akademii Nauk SSSR 315 (1): 229–31. PMID 1965799.
• Tuteja N, Danciger M, Klisak I, et al. (1990). "Isolation and characterization of cDNA encoding the gamma-subunit of cGMP phosphodiesterase in human retina.". Gene 88 (2): 227–32. doi:10.1016/0378-1119(90)90035-P. PMID 2161380.
• Piriev NI, Khramtsov NV, Lipkin VM (1995). "Cloning and characterization of the gene encoding the cGMP-phosphodiesterase gamma-subunit of human rod photoreceptor cells.". Gene 151 (1–2): 297–301. doi:10.1016/0378-1119(94)90674-2. PMID 7828894.
• Hahn LB, Berson EL, Dryja TP (1994). "Evaluation of the gene encoding the gamma subunit of rod phosphodiesterase in retinitis pigmentosa". Invest. Ophthalmol. Vis. Sci. 35 (3): 1077–82. PMID 8125719.
• Dollfus H, Mattei MG, Rozet JM, et al. (1993). "Physical and genetic localization of the gamma subunit of the cyclic GMP phosphodiesterase on the long arm of chromosome 17 (17q25)". Genomics 17 (2): 526–8. doi:10.1006/geno.1993.1364. PMID 8406511.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Wan KF, Sambi BS, Frame M, et al. (2001). "The inhibitory gamma subunit of the type 6 retinal cyclic guanosine monophosphate phosphodiesterase is a novel intermediate regulating p42/p44 mitogen-activated protein kinase signaling in human embryonic kidney 293 cells". J. Biol. Chem. 276 (41): 37802–8. doi:10.1074/jbc.M105087200. PMID 11502744.
• Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts". Mol. Vis. 8: 196–204. PMID 12107411.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Wan KF, Sambi BS, Tate R, et al. (2003). "The inhibitory gamma subunit of the type 6 retinal cGMP phosphodiesterase functions to link c-Src and G-protein-coupled receptor kinase 2 in a signaling unit that regulates p42/p44 mitogen-activated protein kinase by epidermal growth factor". J. Biol. Chem. 278 (20): 18658–63. doi:10.1074/jbc.M212103200. PMID 12624098.
• Morin F, Vannier B, Houdart F, et al. (2003). "A proline-rich domain in the gamma subunit of phosphodiesterase 6 mediates interaction with SH3-containing proteins". Mol. Vis. 9: 449–59. PMID 14502124.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

External links

• GeneReviews/NCBI/NIH/UW entry on Retinitis Pigmentosa Overview