PDLIM5

PDZ and LIM domain 5
PDB rendering based on 1wf7.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2DAR​, 2UZC​
Identifiers
Symbols	PDLIM5 ; ENH; ENH1; L9; LIM
External IDs	OMIM: 605904 MGI: 1927489 HomoloGene: 21289 GeneCards: PDLIM5 Gene
Gene ontology Molecular function • actin binding • protein kinase C binding • protein binding • zinc ion binding • actinin binding • protein N-terminus binding Cellular component • cytosol • postsynaptic density • actin cytoskeleton • membrane • Z disc • cell junction • neuron projection • postsynaptic membrane Biological process • regulation of synapse assembly • regulation of dendritic spine morphogenesis • cell growth involved in cardiac muscle cell development Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10611	56376
Ensembl	ENSG00000163110	ENSMUSG00000028273
UniProt	Q96HC4	Q8CI51
RefSeq (mRNA)	NM_001011513	NM_001190852
RefSeq (protein)	NP_001011513	NP_001177781
Location (UCSC)	Chr 4: 94.45 – 94.67 Mb	Chr 3: 142.24 – 142.4 Mb
PubMed search

PDZ and LIM domain protein 5 is a protein that in humans is encoded by the PDLIM5 gene.^[1][2]

The protein encoded by this gene is a LIM domain protein. LIM domains are cysteine-rich double zinc fingers composed of 50 to 60 amino acids that are involved in protein-protein interactions. LIM domain-containing proteins are scaffolds for the formation of multiprotein complexes. The proteins are involved in cytoskeleton organization, cell lineage specification, organ development, and oncogenesis. The encoded protein is also a member of the Enigma class of proteins, a family of proteins that possess a 100-amino acid PDZ domain in the N terminus and 1 to 3 LIM domains in the C terminus. Multiple transcript variants encoding different isoforms have been found for this gene, although not all of them have been fully characterized.^[2]

Interactions

PDLIM5 has been shown to interact with PRKCB1.^[3]

References

1. Wu M, Li Y, Ji C, Xu J, Zheng H, Zou X, Gu S, Lou Y, Xie Y, Mao Y (September 2004). "Cloning and identification of a novel human gene PDLIM5, a homolog of AD-associated neuronal thread protein (AD7c-NTP)". DNA Seq 15 (2): 144–7. doi:10.1080/10425170310001656756. PMID 15346770.
2. "Entrez Gene: PDLIM5 PDZ and LIM domain 5".
3. Kuroda, S; Tokunaga C; Kiyohara Y; Higuchi O; Konishi H; Mizuno K; Gill G N; Kikkawa U (December 1996). "Protein-protein interaction of zinc finger LIM domains with protein kinase C". J. Biol. Chem. (UNITED STATES) 271 (49): 31029–32. doi:10.1074/jbc.271.49.31029. ISSN 0021-9258. PMID 8940095.

Further reading

• Sudo K, Chinen K, Nakamura Y (1995). "2058 expressed sequence tags (ESTs) from a human fetal lung cDNA library". Genomics 24 (2): 276–9. doi:10.1006/geno.1994.1616. PMID 7698749.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Kuroda S, Tokunaga C, Kiyohara Y, et al. (1997). "Protein-protein interaction of zinc finger LIM domains with protein kinase C". J. Biol. Chem. 271 (49): 31029–32. doi:10.1074/jbc.271.49.31029. PMID 8940095.
• Ueki N, Seki N, Yano K, et al. (1999). "Isolation, tissue expression, and chromosomal assignment of a human LIM protein gene, showing homology to rat enigma homologue (ENH)". J. Hum. Genet. 44 (4): 256–60. doi:10.1007/s100380050155. PMID 10429367.
• Nakagawa N, Hoshijima M, Oyasu M, et al. (2000). "ENH, containing PDZ and LIM domains, heart/skeletal muscle-specific protein, associates with cytoskeletal proteins through the PDZ domain". Biochem. Biophys. Res. Commun. 272 (2): 505–12. doi:10.1006/bbrc.2000.2787. PMID 10833443.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Maeno-Hikichi Y, Chang S, Matsumura K, et al. (2003). "A PKC epsilon-ENH-channel complex specifically modulates N-type Ca2+ channels". Nat. Neurosci. 6 (5): 468–75. doi:10.1038/nn1041. PMID 12665800.
• Iwamoto K, Kakiuchi C, Bundo M, et al. (2004). "Molecular characterization of bipolar disorder by comparing gene expression profiles of postmortem brains of major mental disorders". Mol. Psychiatry 9 (4): 406–16. doi:10.1038/sj.mp.4001437. PMID 14743183.
• Petroziello J, Yamane A, Westendorf L, et al. (2004). "Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer". Oncogene 23 (46): 7734–45. doi:10.1038/sj.onc.1207921. PMID 15334068.
• Iwamoto K, Bundo M, Washizuka S, et al. (2004). "Expression of HSPF1 and LIM in the lymphoblastoid cells derived from patients with bipolar disorder and schizophrenia". J. Hum. Genet. 49 (5): 227–31. doi:10.1007/s10038-004-0136-5. PMID 15362566.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Niederländer N, Fayein NA, Auffray C, Pomiès P (2005). "Characterization of a new human isoform of the enigma homolog family specifically expressed in skeletal muscle". Biochem. Biophys. Res. Commun. 325 (4): 1304–11. doi:10.1016/j.bbrc.2004.10.178. PMID 15555569.
• Kato T, Iwayama Y, Kakiuchi C, et al. (2005). "Gene expression and association analyses of LIM (PDLIM5) in bipolar disorder and schizophrenia". Mol. Psychiatry 10 (11): 1045–55. doi:10.1038/sj.mp.4001719. PMID 16044170.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Horiuchi Y, Arai M, Niizato K, et al. (2006). "A polymorphism in the PDLIM5 gene associated with gene expression and schizophrenia". Biol. Psychiatry 59 (5): 434–9. doi:10.1016/j.biopsych.2005.07.041. PMID 16213469.