PD 144418

PD 144418
Systematic (IUPAC) name

1,2,3,6-tetrahydro-5-[3-(4-methylphenyl)-5-isoxazolyl]-1-propylpyridine
Identifiers
CAS Number	154130-99-1
ChemSpider	7992981
Chemical data
Formula	C₁₈H₂₂N₂O
Molar mass	282.38 g/mol
SMILES CCCN1CCC=C(C1)C2=CC(=NO2)C3=CC=C(C=C3)C
InChI InChI=1S/C18H22N2O/c1-3-10-20-11-4-5-16(13-20)18-12-17(19-21-18)15-8-6-14(2)7-9-15/h5-9,12H,3-4,10-11,13H2,1-2H3 Key:FOQRKFCLRMMKAT-UHFFFAOYSA-N

PD 144418 or 1,2,3,6-tetrahydro-5-[3-(4-methylphenyl)-5-isoxazolyl]-1-propylpyridine is a potent and selective ligand for the sigma-1 receptor, with a reported binding affinity of K_i = 0.08 ± 0.01 nM, and 17 212 times selectivity over the sigma-2 receptor.^[1]

References

↑ Akunne HC, Whetzel SZ, Wiley JN, Corbin AE, Ninteman FW, Tecle H, Pei Y, Pugsley TA, Heffner TG (January 1997). "The pharmacology of the novel and selective sigma ligand, PD 144418". Neuropharmacology 36 (1): 51–62. doi:10.1016/S0028-3908(96)00161-X. PMID 9144641.

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