PEG 400

Polyethylene glycol

Names
IUPAC name Polyethylene glycol
Identifiers
CAS Number	25322-68-3
Properties
Chemical formula	C2nH4n+2On+1, n = 8.2 to 9.1
Molar mass	380-420 g/mol
Density	1.128 g/cm^3
Melting point	4 to 8 Â°C (39 to 46 Â°F; 277 to 281 K)
Viscosity	90.0 cSt at 25 °C, 7.3 cSt at 99 °C
Hazards
Flash point	238 Â°C (460 Â°F; 511 K)
Lethal dose or concentration (LD, LC):
LD50 (Median dose)	30 mL/kg, orally in rats
Except where otherwise noted, data are given for materials in their standard state (at 25 Â°C [77 Â°F], 100 kPa).
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Infobox references

PEG 400 (polyethylene glycol 400) is a low-molecular-weight grade of polyethylene glycol. It is a clear, colorless, viscous liquid. Due in part to its low toxicity, PEG 400 is widely used in a variety of pharmaceutical formulations.

Chemical properties

PEG 400 is strongly hydrophilic. The partition coefficient of PEG 400 between hexane and water is 0.000015 (log$P = -4.8$), indicating that when PEG 400 is mixed with water and hexane, there are only 15 parts of PEG 400 in the hexane layer per 1 million parts of PEG 400 in the water layer.^[1]

PEG 400 is soluble in water, acetone, alcohols, benzene, glycerin, glycols, and aromatic hydrocarbons, and is slightly soluble in aliphatic hydrocarbons.

References

1. T. Y. Ma, D. Hollander, P. Krugliak, K. Katz (1990). "PEG 400, a hydrophilic molecular probe for measuring intestinal permeability". Gastroenterology 98 (1): 39–46. PMID 2293598.

• The Merck Index, 11th Edition
• Handbook of Pharmaceutical Excipients