PEX14

Peroxisomal biogenesis factor 14

Rendering based on PDB 2W84.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PEX14 ; NAPP2; PBD13A; Pex14p; dJ734G22.2
External IDs OMIM: 601791 MGI: 1927868 HomoloGene: 37936 GeneCards: PEX14 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 5195 56273
Ensembl ENSG00000142655 ENSMUSG00000028975
UniProt O75381 Q9R0A0
RefSeq (mRNA) NM_004565 NM_019781
RefSeq (protein) NP_004556 NP_062755
Location (UCSC) Chr 1:
10.47 – 10.63 Mb
Chr 4:
148.96 – 149.1 Mb
PubMed search
Peroxisomal membrane anchor protein (Pex14p) conserved region
Identifiers
Symbol Pex14_N
Pfam PF04695
InterPro IPR006785

Peroxisomal membrane protein PEX14 is a protein that in humans is encoded by the PEX14 gene.[1][2]

Function

This gene encodes an essential component of the peroxisomal import machinery. The protein is integrated into peroxisome membranes with its C-terminus exposed to the cytosol, and interacts with the cytosolic receptor for proteins containing a PTS1 peroxisomal targeting signal. The protein also functions as a transcriptional corepressor and interacts with a histone deacetylase. A mutation in this gene results in one form of Zellweger syndrome.[2]

Interactions

PEX14 has been shown to interact with

References

  1. Fransen M, Terlecky SR, Subramani S (Jul 1998). "Identification of a human PTS1 receptor docking protein directly required for peroxisomal protein import". Proceedings of the National Academy of Sciences of the United States of America 95 (14): 8087–92. doi:10.1073/pnas.95.14.8087. PMC 20933. PMID 9653144.
  2. 1 2 "Entrez Gene: PEX14 peroxisomal biogenesis factor 14".
  3. 1 2 Otera H, Setoguchi K, Hamasaki M, Kumashiro T, Shimizu N, Fujiki Y (Mar 2002). "Peroxisomal targeting signal receptor Pex5p interacts with cargoes and import machinery components in a spatiotemporally differentiated manner: conserved Pex5p WXXXF/Y motifs are critical for matrix protein import". Molecular and Cellular Biology 22 (6): 1639–55. doi:10.1128/MCB.22.6.1639-1655.2002. PMC 135613. PMID 11865044.
  4. Okumoto K, Abe I, Fujiki Y (Aug 2000). "Molecular anatomy of the peroxin Pex12p: ring finger domain is essential for Pex12p function and interacts with the peroxisome-targeting signal type 1-receptor Pex5p and a ring peroxin, Pex10p". The Journal of Biological Chemistry 275 (33): 25700–10. doi:10.1074/jbc.M003303200. PMID 10837480.
  5. Shimizu N, Itoh R, Hirono Y, Otera H, Ghaedi K, Tateishi K, Tamura S, Okumoto K, Harano T, Mukai S, Fujiki Y (Apr 1999). "The peroxin Pex14p. cDNA cloning by functional complementation on a Chinese hamster ovary cell mutant, characterization, and functional analysis". The Journal of Biological Chemistry 274 (18): 12593–604. doi:10.1074/jbc.274.18.12593. PMID 10212238.
  6. 1 2 Managadze D, Würtz C, Sichting M, Niehaus G, Veenhuis M, Rottensteiner H (Jun 2007). "The peroxin PEX14 of Neurospora crassa is essential for the biogenesis of both glyoxysomes and Woronin bodies". Traffic 8 (6): 687–701. doi:10.1111/j.1600-0854.2007.00560.x. PMID 17461798.

Further reading

External links

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