PEX16

Peroxisomal biogenesis factor 16
Identifiers
Symbols PEX16 ; PBD8A; PBD8B
External IDs OMIM: 603360 MGI: 1338829 HomoloGene: 3537 GeneCards: PEX16 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 9409 18633
Ensembl ENSG00000121680 ENSMUSG00000027222
UniProt Q9Y5Y5 Q91XC9
RefSeq (mRNA) NM_004813 NM_145122
RefSeq (protein) NP_004804 NP_660104
Location (UCSC) Chr 11:
45.91 – 45.92 Mb
Chr 2:
92.37 – 92.38 Mb
PubMed search

Peroxisomal membrane protein PEX16 is a protein that in humans is encoded by the PEX16 gene.[1][2]

Function

The protein encoded by this gene is an integral peroxisomal membrane protein. An inactivating nonsense mutation localized to this gene was observed in a patient with Zellweger syndrome of the complementation group CGD/CG9. Expression of this gene product morphologically and biochemically restores the formation of new peroxisomes, suggesting a role in peroxisome organization and biogenesis. Alternative splicing has been observed for this gene and two variants have been described.[2]

Interactions

PEX16 has been shown to interact with PEX19.[3]

References

Further reading

External links


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