PFDN5

Prefoldin subunit 5
Identifiers
Symbols	PFDN5 ; MM-1; MM1; PFD5
External IDs	OMIM: 604899 MGI: 1928753 HomoloGene: 1972 GeneCards: PFDN5 Gene
Gene ontology Molecular function • transcription corepressor activity • protein binding • unfolded protein binding Cellular component • nucleus • cytoplasm • prefoldin complex Biological process • regulation of transcription, DNA-templated • protein folding • cellular protein metabolic process • negative regulation of transcription, DNA-templated • 'de novo' posttranslational protein folding • retina development in camera-type eye • negative regulation of canonical Wnt signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5204	56612
Ensembl	ENSG00000123349	ENSMUSG00000001289
UniProt	Q99471	Q9WU28
RefSeq (mRNA)	NM_002624	NM_020031
RefSeq (protein)	NP_002615	NP_081320
Location (UCSC)	Chr 12: 53.3 – 53.3 Mb	Chr 15: 102.33 – 102.33 Mb
PubMed search

Prefoldin subunit 5 is a protein that in humans is encoded by the PFDN5 gene.^[1][2][3]

This gene encodes a member of the prefoldin alpha subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. The encoded protein may also repress the transcriptional activity of the proto-oncogene c-Myc. Alternatively spliced transcript variants encoding different isoforms have been described.^[3]

Interactions

PFDN5 has been shown to interact with Myc.^[2][4]

References

1. Vainberg IE, Lewis SA, Rommelaere H, Ampe C, Vandekerckhove J, Klein HL, Cowan NJ (Jul 1998). "Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin". Cell 93 (5): 863–873. doi:10.1016/S0092-8674(00)81446-4. PMID 9630229.
2. Mori K, Maeda Y, Kitaura H, Taira T, Iguchi-Ariga SM, Ariga H (Dec 1998). "MM-1, a novel c-Myc-associating protein that represses transcriptional activity of c-Myc". J Biol Chem 273 (45): 29794–29800. doi:10.1074/jbc.273.45.29794. PMID 9792694.
3. "Entrez Gene: PFDN5 prefoldin subunit 5".
4. Fujioka, Y; Taira T; Maeda Y; Tanaka S; Nishihara H; Iguchi-Ariga S M; Nagashima K; Ariga H (Nov 2001). "MM-1, a c-Myc-binding protein, is a candidate for a tumor suppressor in leukemia/lymphoma and tongue cancer". J. Biol. Chem. (United States) 276 (48): 45137–45144. doi:10.1074/jbc.M106127200. ISSN 0021-9258. PMID 11567024.

Further reading

• Hansen WJ, Cowan NJ, Welch WJ (1999). "Prefoldin-nascent chain complexes in the folding of cytoskeletal proteins". J. Cell Biol. 145 (2): 265–277. doi:10.1083/jcb.145.2.265. PMC 2133115. PMID 10209023.
• Cowan NJ, Lewis SA (2002). "A chaperone with a hydrophilic surface". Nat. Struct. Biol. 6 (11): 990–991. doi:10.1038/14870. PMID 10542082.
• Rommelaere H, De Neve M, Neirynck K, et al. (2001). "Prefoldin recognition motifs in the nonhomologous proteins of the actin and tubulin families". J. Biol. Chem. 276 (44): 41023–41028. doi:10.1074/jbc.M106591200. PMID 11535601.
• Fujioka Y, Taira T, Maeda Y, et al. (2002). "MM-1, a c-Myc-binding protein, is a candidate for a tumor suppressor in leukemia/lymphoma and tongue cancer". J. Biol. Chem. 276 (48): 45137–45144. doi:10.1074/jbc.M106127200. PMID 11567024.
• Watanabe K, Ozaki T, Nakagawa T, et al. (2002). "Physical interaction of p73 with c-Myc and MM1, a c-Myc-binding protein, and modulation of the p73 function". J. Biol. Chem. 277 (17): 15113–15123. doi:10.1074/jbc.M111281200. PMID 11844794.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Simons CT, Staes A, Rommelaere H, et al. (2004). "Selective contribution of eukaryotic prefoldin subunits to actin and tubulin binding". J. Biol. Chem. 279 (6): 4196–4203. doi:10.1074/jbc.M306053200. PMID 14634002.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Bruneel A, Labas V, Mailloux A, et al. (2006). "Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis". Proteomics 5 (15): 3876–3884. doi:10.1002/pmic.200401239. PMID 16130169.
• Hagio Y, Kimura Y, Taira T, et al. (2006). "Distinct localizations and repression activities of MM-1 isoforms toward c-Myc". J. Cell. Biochem. 97 (1): 145–155. doi:10.1002/jcb.20619. PMID 16173081.