PFKFB3

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PDB rendering based on 2axn.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2AXN​, 2DWO​, 2DWP​, 2I1V​, 3QPU​, 3QPV​, 3QPW​, 4MA4​, 5AJV​, 5AJW​, 5AJX​, 5AJY​, 5AJZ​, 5AK0​
Identifiers
Symbols	PFKFB3 ; IPFK2; PFK2
External IDs	OMIM: 605319 MGI: 2181202 HomoloGene: 88708 GeneCards: PFKFB3 Gene
EC number	2.7.1.105, 3.1.3.46
Gene ontology Molecular function • 6-phosphofructo-2-kinase activity • fructose-2,6-bisphosphate 2-phosphatase activity • ATP binding Cellular component • nucleoplasm • cytosol Biological process • carbohydrate metabolic process • fructose metabolic process • fructose 2,6-bisphosphate metabolic process • glucose metabolic process • protein dephosphorylation • brain development • small molecule metabolic process • carbohydrate phosphorylation • canonical glycolysis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5209	170768
Ensembl	ENSG00000170525	ENSMUSG00000026773
UniProt	Q16875	A2AUP1
RefSeq (mRNA)	NM_001145443	NM_001177752
RefSeq (protein)	NP_001138915	NP_001171223
Location (UCSC)	Chr 10: 6.14 – 6.24 Mb	Chr 2: 11.47 – 11.55 Mb
PubMed search

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 is an enzyme that in humans is encoded by the PFKFB3 gene.^[1][2][3]

References

1. Nicholl J, Hamilton JA, Sutherland GR, Sutherland RL, Watts CK (Jun 1997). "The third human isoform of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB3) map position 10p14-p15". Chromosome Res 5 (2): 150. PMID 9146922.
2. Manzano A, Rosa JL, Ventura F, Perez JX, Nadal M, Estivill X, Ambrosio S, Gil J, Bartrons R (Mar 1999). "Molecular cloning, expression, and chromosomal localization of a ubiquitously expressed human 6-phosphofructo-2-kinase/ fructose-2, 6-bisphosphatase gene (PFKFB3)". Cytogenet Cell Genet 83 (3–4): 214–7. doi:10.1159/000015181. PMID 10072580.
3. "Entrez Gene: PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3".

Further reading

• Sakai A, Kato M, Fukasawa M, et al. (1996). "Cloning of cDNA encoding for a novel isozyme of fructose 6-phosphate, 2-kinase/fructose 2,6-bisphosphatase from human placenta". J. Biochem. 119 (3): 506–11. doi:10.1093/oxfordjournals.jbchem.a021270. PMID 8830046.
• Hamilton JA, Callaghan MJ, Sutherland RL, Watts CK (1997). "Identification of PRG1, a novel progestin-responsive gene with sequence homology to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase". Mol. Endocrinol. 11 (4): 490–502. doi:10.1210/me.11.4.490. PMID 9092801.
• Sakakibara R, Kato M, Okamura N, et al. (1997). "Characterization of a human placental fructose-6-phosphate, 2-kinase/fructose-2,6-bisphosphatase". J. Biochem. 122 (1): 122–8. doi:10.1093/oxfordjournals.jbchem.a021719. PMID 9276680.
• Scanlan MJ, Gordan JD, Williamson B, et al. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int. J. Cancer 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479.
• Fukasawa M, Takayama E, Shinomiya N, et al. (2000). "Identification of the promoter region of human placental 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene". Biochem. Biophys. Res. Commun. 267 (3): 703–8. doi:10.1006/bbrc.1999.2022. PMID 10673355.
• Kessler R, Eschrich K (2001). "Splice isoforms of ubiquitous 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase in human brain". Brain Res. Mol. Brain Res. 87 (2): 190–5. doi:10.1016/S0169-328X(01)00014-6. PMID 11245921.
• Navarro-Sabaté A, Manzano A, Riera L, et al. (2001). "The human ubiquitous 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene (PFKFB3): promoter characterization and genomic structure". Gene 264 (1): 131–8. doi:10.1016/S0378-1119(00)00591-6. PMID 11245987.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Riera L, Obach M, Navarro-Sabaté A, et al. (2003). "Regulation of ubiquitous 6-phosphofructo-2-kinase by the ubiquitin-proteasome proteolytic pathway during myogenic C2C12 cell differentiation". FEBS Lett. 550 (1–3): 23–9. doi:10.1016/S0014-5793(03)00808-1. PMID 12935880.
• Obach M, Navarro-Sabaté A, Caro J, et al. (2005). "6-Phosphofructo-2-kinase (pfkfb3) gene promoter contains hypoxia-inducible factor-1 binding sites necessary for transactivation in response to hypoxia". J. Biol. Chem. 279 (51): 53562–70. doi:10.1074/jbc.M406096200. PMID 15466858.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Manes NP, El-Maghrabi MR (2005). "The kinase activity of human brain 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase is regulated via inhibition by phosphoenolpyruvate". Arch. Biochem. Biophys. 438 (2): 125–36. doi:10.1016/j.abb.2005.04.011. PMID 15896703.
• Minchenko OH, Ogura T, Opentanova IL, et al. (2006). "Splice isoform of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-4: expression and hypoxic regulation". Mol. Cell. Biochem. 280 (1–2): 227–34. doi:10.1007/s11010-005-8009-6. PMID 16311927.