PGLYRP2

Peptidoglycan recognition protein 2
Identifiers
Symbols	PGLYRP2 ; HMFT0141; PGLYRPL; PGRP-L; PGRPL; TAGL-like; tagL; tagL-alpha; tagl-beta
External IDs	OMIM: 608199 HomoloGene: 49671 GeneCards: PGLYRP2 Gene
EC number	3.5.1.28
Gene ontology Molecular function • zinc ion binding • N-acetylmuramoyl-L-alanine amidase activity • peptidoglycan receptor activity • peptidoglycan binding Cellular component • intracellular • membrane • extracellular exosome Biological process • peptide amidation • pattern recognition receptor signaling pathway • peptidoglycan catabolic process • detection of bacterium • negative regulation of interferon-gamma production • negative regulation of natural killer cell differentiation involved in immune response • growth of symbiont in host • innate immune response • regulation of inflammatory response • defense response to Gram-positive bacterium Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	114770	57757
Ensembl	ENSG00000161031	ENSMUSG00000079563
UniProt	Q96PD5	Q8VCS0
RefSeq (mRNA)	NM_052890	NM_001271476
RefSeq (protein)	NP_443122	NP_001258405
Location (UCSC)	Chr 19: 15.47 – 15.5 Mb	Chr 17: 32.41 – 32.42 Mb
PubMed search

PGLYRP2 is a gene encoding a protein with N-acetylmuramoyl-L-alanine amidase activity.^[1][2][3]

Peptidoglycan recognition proteins, such as PGRPL, are part of the innate immune system and recognize peptidoglycan, a ubiquitous component of bacterial cell walls.[supplied by OMIM]^[3]

See Also

• Peptidoglycan
• Innate immune system
• Bacterial cell walls

References

1. Liu C, Xu Z, Gupta D, Dziarski R (Sep 2001). "Peptidoglycan recognition proteins: a novel family of four human innate immunity pattern recognition molecules". J Biol Chem 276 (37): 34686–94. doi:10.1074/jbc.M105566200. PMID 11461926.
2. Kibardin AV, Mirkina II, Zakeeva IR, Baranova EV, Georgiev GP, Kiselev SL (Apr 2003). "[Expression analysis of proteins encoded by genes of the tag7/tagL (PGRP-S,L) family in human peripheral blood cells]". Genetika 39 (2): 244–9. PMID 12669421.
3. "Entrez Gene: PGLYRP2 peptidoglycan recognition protein 2".

Further reading

• De Pauw P, Neyt C, Vanderwinkel E, et al. (1995). "Characterization of human serum N-acetylmuramyl-L-alanine amidase purified by affinity chromatography.". Protein Expr. Purif. 6 (3): 371–8. doi:10.1006/prep.1995.1049. PMID 7663175.
• Dehal P, Predki P, Olsen AS, et al. (2001). "Human chromosome 19 and related regions in mouse: conservative and lineage-specific evolution.". Science 293 (5527): 104–11. doi:10.1126/science.1060310. PMID 11441184.
• Xu XR, Huang J, Xu ZG, et al. (2002). "Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver.". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 15089–94. doi:10.1073/pnas.241522398. PMC 64988. PMID 11752456.
• Zhang H, Li XJ, Martin DB, Aebersold R (2003). "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.". Nat. Biotechnol. 21 (6): 660–6. doi:10.1038/nbt827. PMID 12754519.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Wang ZM, Li X, Cocklin RR, et al. (2004). "Human peptidoglycan recognition protein-L is an N-acetylmuramoyl-L-alanine amidase.". J. Biol. Chem. 278 (49): 49044–52. doi:10.1074/jbc.M307758200. PMID 14506276.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Yamada S, Ohira M, Horie H, et al. (2004). "Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas.". Oncogene 23 (35): 5901–11. doi:10.1038/sj.onc.1207782. PMID 15221005.
• Xu M, Wang Z, Locksley RM (2004). "Innate immune responses in peptidoglycan recognition protein L-deficient mice.". Mol. Cell. Biol. 24 (18): 7949–57. doi:10.1128/MCB.24.18.7949-7957.2004. PMC 515053. PMID 15340057.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Zhang Y, van der Fits L, Voerman JS, et al. (2005). "Identification of serum N-acetylmuramoyl-l-alanine amidase as liver peptidoglycan recognition protein 2.". Biochim. Biophys. Acta 1752 (1): 34–46. doi:10.1016/j.bbapap.2005.07.001. PMID 16054449.
• Wang H, Gupta D, Li X, Dziarski R (2005). "Peptidoglycan recognition protein 2 (N-acetylmuramoyl-L-Ala amidase) is induced in keratinocytes by bacteria through the p38 kinase pathway.". Infect. Immun. 73 (11): 7216–25. doi:10.1128/IAI.73.11.7216-7225.2005. PMC 1273900. PMID 16239516.
• Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Li X, Wang S, Wang H, Gupta D (2006). "Differential expression of peptidoglycan recognition protein 2 in the skin and liver requires different transcription factors.". J. Biol. Chem. 281 (30): 20738–48. doi:10.1074/jbc.M601017200. PMID 16714290.