PHACTR3

Phosphatase and actin regulator 3
Identifiers
Symbols	PHACTR3 ; C20orf101; H17739; PPP1R123; SCAPIN1; SCAPININ
External IDs	OMIM: 608725 MGI: 1921439 HomoloGene: 14482 GeneCards: PHACTR3 Gene
Gene ontology Molecular function • actin binding • protein phosphatase inhibitor activity • protein phosphatase 1 binding • protein phosphatase type 1 regulator activity Cellular component • nucleoplasm • nuclear matrix Biological process • negative regulation of catalytic activity Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	116154	74189
Ensembl	ENSG00000087495	ENSMUSG00000027525
UniProt	Q96KR7	Q8BYK5
RefSeq (mRNA)	NM_001199505	NM_001007154
RefSeq (protein)	NP_001186434	NP_001007155
Location (UCSC)	Chr 20: 59.58 – 59.85 Mb	Chr 2: 178.12 – 178.34 Mb
PubMed search

Phosphatase and actin regulator 3 is an enzyme that in humans is encoded by the PHACTR3 gene.^[1][2]

Function

The protein encoded by this gene is associated with the nuclear scaffold in proliferating cells. It was found to bind to the catalytic subunit of protein phosphatase-1 (PP1) and inhibit PP1 activity, suggesting that this protein may function as a regulatory subunit of PP1. Alternative splicing at this locus results in several transcript variants encoding different isoforms.^[2]

Interactions

PHACTR3 has been shown to interact with PPP1CA.^[3]

References

1. Allen PB, Greenfield AT, Svenningsson P, Haspeslagh DC, Greengard P (May 2004). "Phactrs 1-4: A family of protein phosphatase 1 and actin regulatory proteins". Proc Natl Acad Sci U S A 101 (18): 7187–92. doi:10.1073/pnas.0401673101. PMC 406487. PMID 15107502.
2. "Entrez Gene: PHACTR3 phosphatase and actin regulator 3".
3. Sagara J, Higuchi T, Hattori Y, Moriya M, Sarvotham H, Shima H, Shirato H, Kikuchi K, Taniguchi S (Nov 2003). "Scapinin, a putative protein phosphatase-1 regulatory subunit associated with the nuclear nonchromatin structure". J. Biol. Chem. 278 (46): 45611–9. doi:10.1074/jbc.M305227200. PMID 12925532.

Further reading

• Worch S, Fiedler E, Hansmann I, Schlote D (2006). "Genomic organization and expression pattern of scapinin (PHACTR3) in mouse and human.". Cytogenet. Genome Res. 115 (1): 23–9. doi:10.1159/000094797. PMID 16974080.
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Sagara J, Higuchi T, Hattori Y, Moriya M, Sarvotham H, Shima H, Shirato H, Kikuchi K, Taniguchi S (2003). "Scapinin, a putative protein phosphatase-1 regulatory subunit associated with the nuclear nonchromatin structure.". J. Biol. Chem. 278 (46): 45611–9. doi:10.1074/jbc.M305227200. PMID 12925532.