PHC3

Polyhomeotic homolog 3 (Drosophila)
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4PZN​, 4PZO​
Identifiers
Symbols	PHC3 ; EDR3; HPH3
External IDs	MGI: 2181434 HomoloGene: 69390 GeneCards: PHC3 Gene
Gene ontology Molecular function • DNA binding • protein binding • zinc ion binding Cellular component • nucleus • nucleoplasm • actin cytoskeleton • PcG protein complex • PRC1 complex • intracellular membrane-bounded organelle Biological process • multicellular organismal development • protein sumoylation • post-translational protein modification • cellular protein metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	80012	241915
Ensembl	ENSG00000173889	ENSMUSG00000037652
UniProt	Q8NDX5	Q8CHP6
RefSeq (mRNA)	NM_001308116	NM_001165954
RefSeq (protein)	NP_001295045	NP_001159426
Location (UCSC)	Chr 3: 170.09 – 170.18 Mb	Chr 3: 30.9 – 30.97 Mb
PubMed search

Polyhomeotic-like protein 3 is a protein that in humans is encoded by the PHC3 gene.^[1][2][3]

References

1. Levine SS, Weiss A, Erdjument-Bromage H, Shao Z, Tempst P, Kingston RE (Aug 2002). "The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans". Mol Cell Biol 22 (17): 6070–6078. doi:10.1128/MCB.22.17.6070-6078.2002. PMC 134016. PMID 12167701.
2. Tonkin E, Hagan DM, Li W, Strachan T (Oct 2002). "Identification and characterisation of novel mammalian homologues of Drosophila polyhomeoticpermits new insights into relationships between members of the polyhomeotic family". Hum Genet 111 (4–5): 435–442. doi:10.1007/s00439-002-0814-3. PMID 12384788.
3. "Entrez Gene: PHC3 polyhomeotic homolog 3 (Drosophila)".

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–12135. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–1718. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–5396. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
• Deshpande AM, Akunowicz JD, Reveles XT, et al. (2007). "PHC3, a component of the hPRC-H complex, associates with E2F6 during G0 and is lost in osteosarcoma tumors". Oncogene 26 (12): 1714–1722. doi:10.1038/sj.onc.1209988. PMC 2691996. PMID 17001316.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983.