PHF12

PHD finger protein 12
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2L9S​, 2LKM​
Identifiers
Symbols	PHF12 ; PF1
External IDs	MGI: 1924057 HomoloGene: 10841 GeneCards: PHF12 Gene
Gene ontology Molecular function • RNA polymerase II transcription corepressor activity • transcription corepressor binding • protein binding • zinc ion binding • phosphatidylinositol binding Cellular component • nucleus • nucleoplasm • nucleolus • Sin3 complex • transcriptional repressor complex Biological process • negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • negative regulation of transcription, DNA-templated Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	57649	268448
Ensembl	ENSG00000109118	ENSMUSG00000037791
UniProt	Q96QT6	Q5SPL2
RefSeq (mRNA)	NM_001033561	NM_174852
RefSeq (protein)	NP_001028733	NP_777277
Location (UCSC)	Chr 17: 28.91 – 28.95 Mb	Chr 11: 77.98 – 78.03 Mb
PubMed search

PHD finger protein 12 is a protein that in humans is encoded by the PHF12 gene.^[1][2]

Interactions

PHF12 has been shown to interact with SIN3A.^[1]

References

1. Yochum GS, Ayer DE (Jun 2001). "Pf1, a Novel PHD Zinc Finger Protein That Links the TLE Corepressor to the mSin3A-Histone Deacetylase Complex". Mol Cell Biol 21 (13): 4110–8. doi:10.1128/MCB.21.13.4110-4118.2001. PMC 87072. PMID 11390640.
2. "Entrez Gene: PHF12 PHD finger protein 12".

Further reading

• Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Yochum GS, Ayer DE (2002). "Role for the Mortality Factors MORF4, MRGX, and MRG15 in Transcriptional Repression via Associations with Pf1, mSin3A, and Transducin-Like Enhancer of Split". Mol. Cell. Biol. 22 (22): 7868–76. doi:10.1128/MCB.22.22.7868-7876.2002. PMC 134742. PMID 12391155.
• Nagase T, Kikuno R, Ishikawa K, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.