PHLDA1
| Pleckstrin homology-like domain, family A, member 1 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | PHLDA1 ; DT1P1B11; PHRIP; TDAG51 | ||||||||||||
| External IDs | OMIM: 605335 MGI: 1096880 HomoloGene: 7203 GeneCards: PHLDA1 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 22822 | 21664 | |||||||||||
| Ensembl | ENSG00000139289 | ENSMUSG00000020205 | |||||||||||
| UniProt | Q8WV24 | Q62392 | |||||||||||
| RefSeq (mRNA) | NM_007350 | NM_009344 | |||||||||||
| RefSeq (protein) | NP_031376 | NP_033370 | |||||||||||
| Location (UCSC) |
Chr 12: 76.03 – 76.03 Mb |
Chr 10: 111.51 – 111.51 Mb | |||||||||||
| PubMed search | |||||||||||||
Pleckstrin homology-like domain family A member 1 is a protein that in humans is encoded by the PHLDA1 gene.[1][2][3]
This gene encodes an evolutionarily conserved proline-histidine rich nuclear protein. The encoded protein may play an important role in the anti-apoptotic effects of insulin-like growth factor-1.[3]
Interactions
PHLDA1 has been shown to interact with RPL14,[4] EIF3D[4] and PABPC4.[4]
References
- ↑ Neef R, Kuske MA, Prols E, Johnson JP (Oct 2002). "Identification of the human PHLDA1/TDAG51 gene: down-regulation in metastatic melanoma contributes to apoptosis resistance and growth deregulation". Cancer Res 62 (20): 5920–9. PMID 12384558.
- ↑ Toyoshima Y, Karas M, Yakar S, Dupont J, Lee Helman, LeRoith D (Jun 2004). "TDAG51 mediates the effects of insulin-like growth factor I (IGF-I) on cell survival". J Biol Chem 279 (24): 25898–904. doi:10.1074/jbc.M400661200. PMID 15037619.
- 1 2 "Entrez Gene: PHLDA1 pleckstrin homology-like domain, family A, member 1".
- 1 2 3 Hinz, T; Flindt S; Marx A; Janssen O; Kabelitz D (May 2001). "Inhibition of protein synthesis by the T cell receptor-inducible human TDAG51 gene product". Cell. Signal. (England) 13 (5): 345–52. doi:10.1016/S0898-6568(01)00141-3. ISSN 0898-6568. PMID 11369516.
Further reading
- Reddy PH, Stockburger E, Gillevet P, Tagle DA (1998). "Mapping and characterization of novel (CAG)n repeat cDNAs from adult human brain derived by the oligo capture method.". Genomics 46 (2): 174–82. doi:10.1006/geno.1997.5044. PMID 9417904.
- Kuske MD, Johnson JP (2000). "Assignment of the human PHLDA1 gene to chromosome 12q15 by radiation hybrid mapping.". Cytogenet. Cell Genet. 89 (1–2): 1. doi:10.1159/000015575. PMID 10894922.
- Hinz T, Flindt S, Marx A, et al. (2001). "Inhibition of protein synthesis by the T cell receptor-inducible human TDAG51 gene product". Cell. Signal. 13 (5): 345–52. doi:10.1016/S0898-6568(01)00141-3. PMID 11369516.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Hossain GS, van Thienen JV, Werstuck GH, et al. (2003). "TDAG51 is induced by homocysteine, promotes detachment-mediated programmed cell death, and contributes to the cevelopment of atherosclerosis in hyperhomocysteinemia". J. Biol. Chem. 278 (32): 30317–27. doi:10.1074/jbc.M212897200. PMID 12738777.
- Oberg HH, Sipos B, Kalthoff H, et al. (2005). "Regulation of T-cell death-associated gene 51 (TDAG51) expression in human T-cells". Cell Death Differ. 11 (6): 674–84. doi:10.1038/sj.cdd.4401407. PMID 15002043.
- Meier-Noorden M, Flindt S, Kalinke U, Hinz T (2004). "A CpG-rich bidirectional promoter induces the T-cell death-associated gene 51 and downregulates an inversely oriented transcript during early T-cell activation". Gene 338 (2): 197–207. doi:10.1016/j.gene.2004.05.006. PMID 15315823.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
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