PHLDB2

Pleckstrin homology-like domain, family B, member 2
Identifiers
Symbols	PHLDB2 ; LL5b; LL5beta
External IDs	OMIM: 610298 MGI: 2444981 HomoloGene: 17100 GeneCards: PHLDB2 Gene
Gene ontology Molecular function • protein binding Cellular component • cytoplasm • plasma membrane • focal adhesion • cell leading edge • intermediate filament cytoskeleton • basal cortex Biological process • microtubule cytoskeleton organization • regulation of gastrulation • regulation of epithelial to mesenchymal transition • establishment of protein localization • negative regulation of stress fiber assembly • negative regulation of focal adhesion assembly • regulation of microtubule cytoskeleton organization • negative regulation of wound healing, spreading of epidermal cells • positive regulation of basement membrane assembly involved in embryonic body morphogenesis Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	90102	208177
Ensembl	ENSG00000144824	ENSMUSG00000033149
UniProt	Q86SQ0	Q8K1N2
RefSeq (mRNA)	NM_001134437	NM_001252442
RefSeq (protein)	NP_001127909	NP_001239371
Location (UCSC)	Chr 3: 111.73 – 111.98 Mb	Chr 16: 45.75 – 45.95 Mb
PubMed search

Pleckstrin homology-like domain family B member 2 is a protein that in humans is encoded by the PHLDB2 gene.^[1][2]

Interactions

PHLDB2 has been shown to interact with FLNC.^[1]

References

1. Paranavitane V, Coadwell WJ, Eguinoa A, Hawkins PT, Stephens L (Jan 2003). "LL5beta is a phosphatidylinositol (3,4,5)-trisphosphate sensor that can bind the cytoskeletal adaptor, gamma-filamin". J Biol Chem 278 (2): 1328–35. doi:10.1074/jbc.M208352200. PMID 12376540.
2. "Entrez Gene: PHLDB2 pleckstrin homology-like domain, family B, member 2".

Further reading

• Dowler S, Currie RA, Campbell DG, Deak M, Kular G, Downes CP, Alessi DR (October 2000). "Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities". Biochem. J. 351 (Pt 1): 19–31. doi:10.1042/0264-6021:3510019. PMC 1221362. PMID 11001876.
• Lansbergen G, Grigoriev I, Mimori-Kiyosue Y, Ohtsuka T, Higa S, Kitajima I, Demmers J, Galjart N, Houtsmuller AB, Grosveld F, Akhmanova A (July 2006). "CLASPs attach microtubule plus ends to the cell cortex through a complex with LL5beta". Dev. Cell 11 (1): 21–32. doi:10.1016/j.devcel.2006.05.012. PMID 16824950.
• Hotta A, Kawakatsu T, Nakatani T, Sato T, Matsui C, Sukezane T, Akagi T, Hamaji T, Grigoriev I, Akhmanova A, Takai Y, Mimori-Kiyosue Y (May 2010). "Laminin-based cell adhesion anchors microtubule plus ends to the epithelial cell basal cortex through LL5alpha/beta". J. Cell Biol. 189 (5): 901–17. doi:10.1083/jcb.200910095. PMC 2878951. PMID 20513769.