PHLPP (gene)

PH domain and leucine rich repeat protein phosphatase 1
Identifiers
Symbols	PHLPP1 ; PHLPP; PLEKHE1; SCOP
External IDs	OMIM: 609396 MGI: 2138327 HomoloGene: 11015 GeneCards: PHLPP1 Gene
EC number	3.1.3.16
Gene ontology Molecular function • phosphoprotein phosphatase activity • protein binding • metal ion binding Cellular component • nucleus • cytosol • plasma membrane Biological process • protein dephosphorylation • apoptotic process • epidermal growth factor receptor signaling pathway • fibroblast growth factor receptor signaling pathway • entrainment of circadian clock • Fc-epsilon receptor signaling pathway • regulation of apoptotic process • regulation of MAPK cascade • innate immune response • regulation of JNK cascade • neurotrophin TRK receptor signaling pathway • phosphatidylinositol-mediated signaling • negative regulation of protein kinase B signaling • regulation of p38MAPK cascade Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23239	98432
Ensembl	ENSG00000081913	ENSMUSG00000044340
UniProt	O60346	Q8CHE4
RefSeq (mRNA)	NM_194449	NM_133821
RefSeq (protein)	NP_919431	NP_598582
Location (UCSC)	Chr 18: 62.72 – 62.98 Mb	Chr 1: 106.17 – 106.39 Mb
PubMed search

PH domain and leucine rich repeat protein phosphatase, also known as PHLPP, is an enzyme which in humans is encoded by the PHLPP gene.^[1]

See also

• PHLPP

References

1. "Entrez Gene: PHLPP PH domain and leucine rich repeat protein phosphatase".

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
• Shimizu K, Okada M, Takano A, Nagai K (2000). "SCOP, a novel gene product expressed in a circadian manner in rat suprachiasmatic nucleus.". FEBS Lett. 458 (3): 363–9. doi:10.1016/S0014-5793(99)01190-4. PMID 10570941.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Gao T, Furnari F, Newton AC (2005). "PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth.". Mol. Cell 18 (1): 13–24. doi:10.1016/j.molcel.2005.03.008. PMID 15808505.
• Zhang Y, Wolf-Yadlin A, Ross PL, et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules.". Mol. Cell Proteomics 4 (9): 1240–50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569.
• Nusbaum C, Zody MC, Borowsky ML, et al. (2005). "DNA sequence and analysis of human chromosome 18.". Nature 437 (7058): 551–5. doi:10.1038/nature03983. PMID 16177791.
• Brognard J, Sierecki E, Gao T, Newton AC (2007). "PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms.". Mol. Cell 25 (6): 917–31. doi:10.1016/j.molcel.2007.02.017. PMID 17386267.