PIB5PA

Inositol polyphosphate-5-phosphatase J
Identifiers
Symbols	INPP5J ; INPP5; PIB5PA; PIPP
External IDs	OMIM: 606481 HomoloGene: 8682 GeneCards: INPP5J Gene
EC number	3.1.3.56
Gene ontology Molecular function • inositol-polyphosphate 5-phosphatase activity • protein binding • SH3 domain binding • phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity • inositol-1,4,5-trisphosphate 5-phosphatase activity • inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity Cellular component • ruffle • cytoplasm • cytosol • plasma membrane • growth cone • dendritic shaft Biological process • protein dephosphorylation • phospholipid metabolic process • phosphatidylinositol biosynthetic process • negative regulation of neuron projection development • negative regulation of microtubule polymerization • negative regulation of peptidyl-serine phosphorylation • inositol phosphate metabolic process • small molecule metabolic process • phosphatidylinositol dephosphorylation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	27124	170835
Ensembl	ENSG00000185133	ENSMUSG00000034570
UniProt	Q15735	P59644
RefSeq (mRNA)	NM_001002837	NM_172439
RefSeq (protein)	NP_001002837	NP_766027
Location (UCSC)	Chr 22: 31.12 – 31.13 Mb	Chr 11: 3.49 – 3.5 Mb
PubMed search

Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A is an enzyme that in humans is encoded by the INPP5J gene.^[1][2]

References

1. Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP; et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
2. "Entrez Gene: PIB5PA phosphatidylinositol (4,5) bisphosphate 5-phosphatase, A".

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gurung R, Tan A, Ooms LM, et al. (2003). "Identification of a novel domain in two mammalian inositol-polyphosphate 5-phosphatases that mediates membrane ruffle localization. The inositol 5-phosphatase skip localizes to the endoplasmic reticulum and translocates to membrane ruffles following epidermal growth factor stimulation.". J. Biol. Chem. 278 (13): 11376–85. doi:10.1074/jbc.M209991200. PMID 12536145.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mochizuki Y, Takenawa T (2000). "Novel inositol polyphosphate 5-phosphatase localizes at membrane ruffles.". J. Biol. Chem. 274 (51): 36790–5. doi:10.1074/jbc.274.51.36790. PMID 10593988.
• Krämer J, Aguirre-Arteta AM, Thiel C, et al. (1999). "A novel isoform of the smooth muscle cell differentiation marker smoothelin.". J. Mol. Med. 77 (2): 294–8. doi:10.1007/s001090050352. PMID 10023782.
• "Toward a complete human genome sequence.". Genome Res. 8 (11): 1097–108. 1999. doi:10.1101/gr.8.11.1097. PMID 9847074.