PIK3AP1

Phosphoinositide-3-kinase adaptor protein 1
Identifiers
Symbols	PIK3AP1 ; BCAP
External IDs	OMIM: 607942 MGI: 1933177 HomoloGene: 12848 GeneCards: PIK3AP1 Gene
Gene ontology Molecular function • phosphatidylinositol 3-kinase regulatory subunit binding • identical protein binding Cellular component • cytosol • plasma membrane • membrane Biological process • positive regulation of phosphatidylinositol 3-kinase signaling • negative regulation of toll-like receptor signaling pathway • positive regulation of toll-like receptor signaling pathway • toll-like receptor 2 signaling pathway • toll-like receptor 4 signaling pathway • toll-like receptor 7 signaling pathway • toll-like receptor 9 signaling pathway • regulation of inflammatory response Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	118788	83490
Ensembl	ENSG00000155629	ENSMUSG00000025017
UniProt	Q6ZUJ8	Q9EQ32
RefSeq (mRNA)	NM_152309	NM_031376
RefSeq (protein)	NP_689522	NP_113553
Location (UCSC)	Chr 10: 96.59 – 96.72 Mb	Chr 19: 41.27 – 41.39 Mb
PubMed search

Phosphoinositide 3-kinase adapter protein 1 is an enzyme that in humans is encoded by the PIK3AP1 gene.^[1][2][3]

References

1. Edwards JA, Sethi PK, Scoma AJ, Bannerman RM, Frohman LA (Apr 1976). "A new familial syndrome characterized by pigmentary retinopathy, hypogonadism, mental retardation, nerve deafness and glucose intolerance". Am J Med 60 (1): 23–32. doi:10.1016/0002-9343(76)90529-5. PMID 1251844.
2. Okada T, Maeda A, Iwamatsu A, Gotoh K, Kurosaki T (Jan 2001). "BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation". Immunity 13 (6): 817–27. doi:10.1016/S1074-7613(00)00079-0. PMID 11163197.
3. "Entrez Gene: PIK3AP1 phosphoinositide-3-kinase adaptor protein 1".

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Maruoka M, Suzuki J, Kawata S, et al. (2005). "Identification of B cell adaptor for PI3-kinase (BCAP) as an Abl interactor 1-regulated substrate of Abl kinases". FEBS Lett. 579 (14): 2986–90. doi:10.1016/j.febslet.2005.04.052. PMID 15893754.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.