PIK3C2G

Phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PIK3C2G ; PI3K-C2-gamma; PI3K-C2GAMMA
External IDs OMIM: 609001 MGI: 1203730 HomoloGene: 3362 IUPHAR: 2288 ChEMBL: 1163120 GeneCards: PIK3C2G Gene
EC number 2.7.1.154
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 5288 18705
Ensembl ENSG00000139144 ENSMUSG00000030228
UniProt O75747 O70167
RefSeq (mRNA) NM_001288772 NM_011084
RefSeq (protein) NP_001275701 NP_035214
Location (UCSC) Chr 12:
18.25 – 18.65 Mb
Chr 6:
139.59 – 139.97 Mb
PubMed search

Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide is an enzyme that in humans is encoded by the PIK3C2G gene.[1][2]

The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The biological function of this gene has not yet been determined.[2]

References

  1. Rozycka M, Lu YJ, Brown RA, Lau MR, Shipley JM, Fry MJ (Feb 1999). "cDNA cloning of a third human C2-domain-containing class II phosphoinositide 3-kinase, PI3K-C2gamma, and chromosomal assignment of this gene (PIK3C2G) to 12p12". Genomics 54 (3): 569–74. doi:10.1006/geno.1998.5621. PMID 9878262.
  2. 1 2 "Entrez Gene: PIK3C2G phosphoinositide-3-kinase, class 2, gamma polypeptide".

Further reading

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