PIK3CB

Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
Identifiers
Symbols	PIK3CB ; P110BETA; PI3K; PI3KBETA; PIK3C1
External IDs	OMIM: 602925 MGI: 1922019 HomoloGene: 21250 ChEMBL: 3145 GeneCards: PIK3CB Gene
EC number	2.7.1.153
Gene ontology Molecular function • protein binding • ATP binding • 1-phosphatidylinositol-3-kinase activity • phosphatidylinositol 3-kinase activity • 1-phosphatidylinositol-4-phosphate 3-kinase activity • insulin receptor substrate binding • phosphatidylinositol-4,5-bisphosphate 3-kinase activity Cellular component • nucleus • cytoplasm • cytosol • plasma membrane • phosphatidylinositol 3-kinase complex Biological process • activation of MAPK activity • endothelial cell proliferation • regulation of cell-matrix adhesion • adaptive immune response • protein phosphorylation • phospholipid metabolic process • phosphatidylinositol biosynthetic process • cellular calcium ion homeostasis • autophagy • chemotaxis • inflammatory response • homophilic cell adhesion via plasma membrane adhesion molecules • signal transduction • transmembrane receptor protein tyrosine kinase signaling pathway • epidermal growth factor receptor signaling pathway • G-protein coupled receptor signaling pathway • blood coagulation • insulin receptor signaling pathway • fibroblast growth factor receptor signaling pathway • positive regulation of autophagy • positive regulation of gene expression • phosphatidylinositol 3-kinase signaling • cell migration • platelet activation • phosphatidylinositol-3-phosphate biosynthetic process • Fc-epsilon receptor signaling pathway • Fc-gamma receptor signaling pathway involved in phagocytosis • embryonic cleavage • small molecule metabolic process • innate immune response • phosphatidylinositol phosphorylation • vascular endothelial growth factor receptor signaling pathway • neurotrophin TRK receptor signaling pathway • phosphatidylinositol-mediated signaling • T cell receptor signaling pathway • leukocyte migration • angiogenesis involved in wound healing • cell chemotaxis • platelet aggregation • regulation of clathrin-mediated endocytosis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5291	74769
Ensembl	ENSG00000051382	ENSMUSG00000032462
UniProt	P42338	Q8BTI9
RefSeq (mRNA)	NM_001256045	NM_029094
RefSeq (protein)	NP_001242974	NP_083370
Location (UCSC)	Chr 3: 138.65 – 138.83 Mb	Chr 9: 99.04 – 99.14 Mb
PubMed search

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform is an enzyme that in humans is encoded by the PIK3CB gene.^[1][2]

Phosphoinositide 3-kinases (PI3Ks) phosphorylate the 3-prime OH position of the inositol ring of inositol lipids. They have been implicated as participants in signaling pathways regulating cell growth by virtue of their activation in response to various mitogenic stimuli. PI3Ks are composed of a 110-kD catalytic subunit, such as PIK3CB, and an 85-kD adaptor subunit (Hu et al., 1993).[supplied by OMIM]^[2]

References

1. Hu P, Mondino A, Skolnik EY, Schlessinger J (Jan 1994). "Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85". Mol Cell Biol 13 (12): 7677–88. PMC 364839. PMID 8246984.
2. "Entrez Gene: PIK3CB phosphoinositide-3-kinase, catalytic, beta polypeptide".

Further reading

• Katada T, Kurosu H, Okada T, et al. (1999). "Synergistic activation of a family of phosphoinositide 3-kinase via G-protein coupled and tyrosine kinase-related receptors.". Chem. Phys. Lipids 98 (1-2): 79–86. doi:10.1016/S0009-3084(99)00020-1. PMID 10358930.
• Lee C, Liu QH, Tomkowicz B, et al. (2004). "Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways.". J. Leukoc. Biol. 74 (5): 676–82. doi:10.1189/jlb.0503206. PMID 12960231.
• Carpenter CL, Duckworth BC, Auger KR, et al. (1991). "Purification and characterization of phosphoinositide 3-kinase from rat liver.". J. Biol. Chem. 265 (32): 19704–11. PMID 2174051.
• Bonnefoy-Bérard N, Liu YC, von Willebrand M, et al. (1995). "Inhibition of phosphatidylinositol 3-kinase activity by association with 14-3-3 proteins in T cells.". Proc. Natl. Acad. Sci. U.S.A. 92 (22): 10142–6. doi:10.1073/pnas.92.22.10142. PMC 40752. PMID 7479742.
• Hu P, Schlessinger J (1994). "Direct association of p110 beta phosphatidylinositol 3-kinase with p85 is mediated by an N-terminal fragment of p110 beta.". Mol. Cell. Biol. 14 (4): 2577–83. doi:10.1128/mcb.14.4.2577. PMC 358625. PMID 8139559.
• Milani D, Mazzoni M, Borgatti P, et al. (1996). "Extracellular human immunodeficiency virus type-1 Tat protein activates phosphatidylinositol 3-kinase in PC12 neuronal cells.". J. Biol. Chem. 271 (38): 22961–4. doi:10.1074/jbc.271.38.22961. PMID 8798481.
• Mazerolles F, Barbat C, Fischer A (1997). "Down-regulation of LFA-1-mediated T cell adhesion induced by the HIV envelope glycoprotein gp160 requires phosphatidylinositol-3-kinase activity.". Eur. J. Immunol. 27 (9): 2457–65. doi:10.1002/eji.1830270946. PMID 9341793.
• Borgatti P, Zauli G, Colamussi ML, et al. (1998). "Extracellular HIV-1 Tat protein activates phosphatidylinositol 3- and Akt/PKB kinases in CD4+ T lymphoblastoid Jurkat cells.". Eur. J. Immunol. 27 (11): 2805–11. doi:10.1002/eji.1830271110. PMID 9394803.
• Borgatti P, Zauli G, Cantley LC, Capitani S (1998). "Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells.". Biochem. Biophys. Res. Commun. 242 (2): 332–7. doi:10.1006/bbrc.1997.7877. PMID 9446795.
• Milani D, Mazzoni M, Zauli G, et al. (1998). "HIV-1 Tat induces tyrosine phosphorylation of p125FAK and its association with phosphoinositide 3-kinase in PC12 cells.". AIDS 12 (11): 1275–84. doi:10.1097/00002030-199811000-00008. PMID 9708406.
• Jauliac S, Mazerolles F, Jabado N, et al. (1998). "Ligands of CD4 inhibit the association of phospholipase Cgamma1 with phosphoinositide 3 kinase in T cells: regulation of this association by the phosphoinositide 3 kinase activity.". Eur. J. Immunol. 28 (10): 3183–91. doi:10.1002/(SICI)1521-4141(199810)28:10<3183::AID-IMMU3183>3.0.CO;2-A. PMID 9808187.
• Graness A, Adomeit A, Heinze R, et al. (1998). "A novel mitogenic signaling pathway of bradykinin in the human colon carcinoma cell line SW-480 involves sequential activation of a Gq/11 protein, phosphatidylinositol 3-kinase beta, and protein kinase Cepsilon.". J. Biol. Chem. 273 (48): 32016–22. doi:10.1074/jbc.273.48.32016. PMID 9822674.
• Sotsios Y, Whittaker GC, Westwick J, Ward SG (1999). "The CXC chemokine stromal cell-derived factor activates a Gi-coupled phosphoinositide 3-kinase in T lymphocytes.". J. Immunol. 163 (11): 5954–63. PMID 10570282.
• Park IW, Wang JF, Groopman JE (2001). "HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes.". Blood 97 (2): 352–8. doi:10.1182/blood.V97.2.352. PMID 11154208.
• Zauli G, Milani D, Mirandola P, et al. (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway.". FASEB J. 15 (2): 483–91. doi:10.1096/fj.00-0354com. PMID 11156964.
• Yang H, Wang X, Raizada MK (2001). "Characterization of signal transduction pathway in neurotropic action of angiotensin II in brain neurons.". Endocrinology 142 (8): 3502–11. doi:10.1210/en.142.8.3502. PMID 11459796.
• Steták A, Csermely P, Ullrich A, Kéri G (2001). "Physical and functional interactions between protein tyrosine phosphatase alpha, PI 3-kinase, and PKCdelta.". Biochem. Biophys. Res. Commun. 288 (3): 564–72. doi:10.1006/bbrc.2001.5811. PMID 11676480.
• Ueki K, Yballe CM, Brachmann SM, et al. (2002). "Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase.". Proc. Natl. Acad. Sci. U.S.A. 99 (1): 419–24. doi:10.1073/pnas.012581799. PMC 117575. PMID 11752399.