PILRB

Paired immunoglobin-like type 2 receptor beta
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4NFC​, 4NFD​
Identifiers
Symbols	PILRB ; FDFACT1; FDFACT2
External IDs	OMIM: 605342 HomoloGene: 114502 GeneCards: PILRB Gene
Gene ontology Molecular function • protein binding • MHC class I protein binding Cellular component • integral component of plasma membrane Biological process • transmembrane receptor protein tyrosine kinase signaling pathway • activation of transmembrane receptor protein tyrosine kinase activity Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	29990	170741
Ensembl	ENSG00000121716	ENSMUSG00000066684
UniProt	Q9UKJ0	Q2YFS2
RefSeq (mRNA)	NM_013440	NM_133209
RefSeq (protein)	NP_839956	NP_573472
Location (UCSC)	Chr 7: 100.35 – 100.37 Mb	Chr 5: 137.85 – 137.86 Mb
PubMed search

Paired immunoglobulin-like type 2 receptor beta is a protein that in humans is encoded by the PILRB gene.^[1][2]

Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the non-ITIM-bearing member of the receptor pair, which has a truncated cytoplasmic tail relative to its ITIM-bearing partner and functions in the activating role. Alternative splicing has been observed at this locus and three variants, encoding two distinct isoforms, are described. Additional transcript variants have been identified but their full-length nature has not been determined.^[2]

References

1. Mousseau DD, Banville D, L'Abbe D, Bouchard P, Shen SH (Mar 2000). "PILRalpha, a novel immunoreceptor tyrosine-based inhibitory motif-bearing protein, recruits SHP-1 upon tyrosine phosphorylation and is paired with the truncated counterpart PILRbeta". J Biol Chem 275 (6): 4467–74. doi:10.1074/jbc.275.6.4467. PMID 10660620.
2. "Entrez Gene: PILRB paired immunoglobin-like type 2 receptor beta".

Further reading

• Fournier N, Chalus L, Durand I, et al. (2000). "FDF03, a novel inhibitory receptor of the immunoglobulin superfamily, is expressed by human dendritic and myeloid cells". J. Immunol. 165 (3): 1197–209. doi:10.4049/jimmunol.165.3.1197. PMID 10903717.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Zhu YX, Benn S, Li ZH, et al. (2004). "The SH3–SAM Adaptor HACS1 is Up-regulated in B Cell Activation Signaling Cascades". J. Exp. Med. 200 (6): 737–47. doi:10.1084/jem.20031816. PMC 2211965. PMID 15381729.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
• Wilson MD, Cheung J, Martindale DW, et al. (2006). "Comparative analysis of the paired immunoglobulin-like receptor (PILR) locus in six mammalian genomes: duplication, conversion, and the birth of new genes". Physiol. Genomics 27 (3): 201–18. doi:10.1152/physiolgenomics.00284.2005. PMID 16926269.