PIP4K2B

Phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PDB rendering based on 1bo1.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1BO1​
Identifiers
Symbols	PIP4K2B ; PI5P4KB; PIP5K2B; PIP5KIIB; PIP5KIIbeta; PIP5P4KB
External IDs	OMIM: 603261 MGI: 1934234 HomoloGene: 2634 IUPHAR: 2162 ChEMBL: 5667 GeneCards: PIP4K2B Gene
EC number	2.7.1.149
Gene ontology Molecular function • receptor signaling protein activity • protein binding • ATP binding • 1-phosphatidylinositol-4-phosphate 5-kinase activity • 1-phosphatidylinositol-5-phosphate 4-kinase activity Cellular component • nucleoplasm • autophagosome • endoplasmic reticulum membrane • cytosol • plasma membrane Biological process • phospholipid metabolic process • phosphatidylinositol biosynthetic process • cell surface receptor signaling pathway • regulation of autophagy • intracellular signal transduction • small molecule metabolic process • phosphatidylinositol phosphorylation • positive regulation of autophagosome assembly Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8396	108083
Ensembl	ENSG00000276293	ENSMUSG00000018547
UniProt	P78356	Q80XI4
RefSeq (mRNA)	NM_003559	NM_054051
RefSeq (protein)	NP_003550	NP_473392
Location (UCSC)	Chr 17: 38.77 – 38.8 Mb	Chr 11: 97.72 – 97.74 Mb
PubMed search

Phosphatidylinositol-5-phosphate 4-kinase type-2 beta is an enzyme that in humans is encoded by the PIP4K2B gene.^[1][2][3][4]

The protein encoded by this gene catalyzes the phosphorylation of phosphatidylinositol-4-phosphate on the fifth hydroxyl of the myo-inositol ring to form phosphatidylinositol-4,5-bisphosphate. This gene is a member of the phosphatidylinositol-4-phosphate 5-kinase family. The encoded protein sequence does not show similarity to other kinases, but the protein does exhibit kinase activity. Additionally, the encoded protein interacts with p55 TNF receptor.^[4]

Interactions

PIP4K2B has been shown to interact with TNFRSF1A.^[1]

References

1. Castellino AM, Parker GJ, Boronenkov IV, Anderson RA, Chao MV (Apr 1997). "A novel interaction between the juxtamembrane region of the p55 tumor necrosis factor receptor and phosphatidylinositol-4-phosphate 5-kinase". J Biol Chem 272 (9): 5861–70. doi:10.1074/jbc.272.9.5861. PMID 9038203.
2. Luoh SW, Venkatesan N, Tripathi R (Feb 2004). "Overexpression of the amplified Pip4k2beta gene from 17q11-12 in breast cancer cells confers proliferation advantage". Oncogene 23 (7): 1354–63. doi:10.1038/sj.onc.1207251. PMID 14691457.
3. Rameh LE, Tolias KF, Duckworth BC, Cantley LC (Nov 1997). "A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate". Nature 390 (6656): 192–6. doi:10.1038/36621. PMID 9367159.
4. "Entrez Gene: PIP5K2B phosphatidylinositol-4-phosphate 5-kinase, type II, beta".

Further reading

• Niiro H, Clark EA (2003). "Branches of the B cell antigen receptor pathway are directed by protein conduits Bam32 and Carma1.". Immunity 19 (5): 637–40. doi:10.1016/S1074-7613(03)00303-0. PMID 14614850.
• Carpenter CL (2004). "Btk-dependent regulation of phosphoinositide synthesis.". Biochem. Soc. Trans. 32 (Pt 2): 326–9. doi:10.1042/BST0320326. PMID 15046600.
• Rao VD, Misra S, Boronenkov IV, et al. (1998). "Structure of type IIbeta phosphatidylinositol phosphate kinase: a protein kinase fold flattened for interfacial phosphorylation.". Cell 94 (6): 829–39. doi:10.1016/S0092-8674(00)81741-9. PMID 9753329.
• Boronenkov IV, Loijens JC, Umeda M, Anderson RA (1999). "Phosphoinositide signaling pathways in nuclei are associated with nuclear speckles containing pre-mRNA processing factors.". Mol. Biol. Cell 9 (12): 3547–60. doi:10.1091/mbc.9.12.3547. PMC 25675. PMID 9843587.
• Kutsenko AS, Gizatullin RZ, Al-Amin AN, et al. (2002). "NotI flanking sequences: a tool for gene discovery and verification of the human genome.". Nucleic Acids Res. 30 (14): 3163–70. doi:10.1093/nar/gkf428. PMC 135748. PMID 12136098.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
• Richardson JP, Wang M, Clarke JH, et al. (2007). "Genomic tagging of endogenous type IIbeta phosphatidylinositol 5-phosphate 4-kinase in DT40 cells reveals a nuclear localisation.". Cell. Signal. 19 (6): 1309–14. doi:10.1016/j.cellsig.2007.01.010. PMC 1868964. PMID 17303380.