PIR (gene)

Pirin (iron-binding nuclear protein)
PDB rendering based on 1j1l.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1J1L​, 3ACL​, 4ERO​, 4EWA​, 4EWD​, 4EWE​, 4GUL​, 4HLT​
Identifiers
Symbol	PIR
External IDs	OMIM: 300931 MGI: 1916906 HomoloGene: 2717 GeneCards: PIR Gene
EC number	1.13.11.24
Gene ontology Molecular function • transcription cofactor activity • protein binding • quercetin 2,3-dioxygenase activity • metal ion binding Cellular component • nucleus • cytoplasm Biological process • regulation of transcription, DNA-templated • transcription from RNA polymerase II promoter • monocyte differentiation • oxidation-reduction process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8544	69656
Ensembl	ENSG00000087842	ENSMUSG00000031379
UniProt	O00625	Q9D711
RefSeq (mRNA)	NM_001018109	NM_001301402
RefSeq (protein)	NP_001018119	NP_001288331
Location (UCSC)	Chr X: 15.38 – 15.49 Mb	Chr X: 164.27 – 164.37 Mb
PubMed search

Pirin is a protein that in humans is encoded by the PIR gene.^[1][2]

This gene encodes a member of the cupin superfamily. The encoded protein is an Fe(II)-containing nuclear protein expressed in all tissues of the body and concentrated within dot-like subnuclear structures. Interactions with nuclear factor I/CCAAT box transcription factor as well as B cell lymphoma 3-encoded oncoprotein suggest the encoded protein may act as a transcriptional cofactor and be involved in the regulation of DNA transcription and replication. Alternatively spliced transcript variants have been described.^[2]

Interactions

PIR (gene) has been shown to interact with BCL3.^[3]

References

1. Wendler WM, Kremmer E, Forster R, Winnacker EL (May 1997). "Identification of pirin, a novel highly conserved nuclear protein". J Biol Chem 272 (13): 8482–9. doi:10.1074/jbc.272.13.8482. PMID 9079676.
2. "Entrez Gene: PIR pirin (iron-binding nuclear protein)".
3. Dechend, R; Hirano F; Lehmann K; Heissmeyer V; Ansieau S; Wulczyn F G; Scheidereit C; Leutz A (Jun 1999). "The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators". Oncogene (ENGLAND) 18 (22): 3316–23. doi:10.1038/sj.onc.1202717. ISSN 0950-9232. PMID 10362352.

Further reading

• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Adams M, Jia Z (2005). "Structural and biochemical analysis reveal pirins to possess quercetinase activity.". J. Biol. Chem. 280 (31): 28675–82. doi:10.1074/jbc.M501034200. PMID 15951572.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Pang H, Bartlam M, Zeng Q, et al. (2004). "Crystal structure of human pirin: an iron-binding nuclear protein and transcription cofactor.". J. Biol. Chem. 279 (2): 1491–8. doi:10.1074/jbc.M310022200. PMID 14573596.
• Zeng Q, Li X, Bartlam M, et al. (2004). "Purification, crystallization and preliminary X-ray analysis of human pirin.". Acta Crystallogr. D Biol. Crystallogr. 59 (Pt 8): 1496–8. doi:10.1107/S0907444903012289. PMID 12876364.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Dechend R, Hirano F, Lehmann K, et al. (1999). "The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators.". Oncogene 18 (22): 3316–23. doi:10.1038/sj.onc.1202717. PMID 10362352.