PIR (gene)

Pirin (iron-binding nuclear protein)

PDB rendering based on 1j1l.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbol PIR
External IDs OMIM: 300931 MGI: 1916906 HomoloGene: 2717 GeneCards: PIR Gene
EC number 1.13.11.24
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 8544 69656
Ensembl ENSG00000087842 ENSMUSG00000031379
UniProt O00625 Q9D711
RefSeq (mRNA) NM_001018109 NM_001301402
RefSeq (protein) NP_001018119 NP_001288331
Location (UCSC) Chr X:
15.38 – 15.49 Mb
Chr X:
164.27 – 164.37 Mb
PubMed search

Pirin is a protein that in humans is encoded by the PIR gene.[1][2]

This gene encodes a member of the cupin superfamily. The encoded protein is an Fe(II)-containing nuclear protein expressed in all tissues of the body and concentrated within dot-like subnuclear structures. Interactions with nuclear factor I/CCAAT box transcription factor as well as B cell lymphoma 3-encoded oncoprotein suggest the encoded protein may act as a transcriptional cofactor and be involved in the regulation of DNA transcription and replication. Alternatively spliced transcript variants have been described.[2]

Interactions

PIR (gene) has been shown to interact with BCL3.[3]

References

  1. Wendler WM, Kremmer E, Forster R, Winnacker EL (May 1997). "Identification of pirin, a novel highly conserved nuclear protein". J Biol Chem 272 (13): 8482–9. doi:10.1074/jbc.272.13.8482. PMID 9079676.
  2. 1 2 "Entrez Gene: PIR pirin (iron-binding nuclear protein)".
  3. Dechend, R; Hirano F; Lehmann K; Heissmeyer V; Ansieau S; Wulczyn F G; Scheidereit C; Leutz A (Jun 1999). "The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators". Oncogene (ENGLAND) 18 (22): 3316–23. doi:10.1038/sj.onc.1202717. ISSN 0950-9232. PMID 10362352.

Further reading

This article is issued from Wikipedia - version of the Wednesday, September 02, 2015. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.