PJA1
| Praja ring finger 1, E3 ubiquitin protein ligase | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | PJA1 ; PRAJA1; RNF70 | ||||||||||||
| External IDs | OMIM: 300420 MGI: 1101765 HomoloGene: 129620 GeneCards: PJA1 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 64219 | 18744 | |||||||||||
| Ensembl | ENSG00000181191 | ENSMUSG00000034403 | |||||||||||
| UniProt | Q8NG27 | O55176 | |||||||||||
| RefSeq (mRNA) | NM_001032396 | NM_001083110 | |||||||||||
| RefSeq (protein) | NP_001027568 | NP_001076579 | |||||||||||
| Location (UCSC) |
Chr X: 69.16 – 69.17 Mb |
Chr X: 99.47 – 99.47 Mb | |||||||||||
| PubMed search | |||||||||||||
E3 ubiquitin-protein ligase Praja1 is an enzyme that in humans is encoded by the PJA1 gene.[1][2]
Interactions
PJA1 has been shown to interact with UBE2D2[1]and MAGED1.[3]
References
- 1 2 Yu P, Chen Y, Tagle DA, Cai T (May 2002). "PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain". Genomics 79 (6): 869–74. doi:10.1006/geno.2002.6770. PMID 12036302.
- ↑ "Entrez Gene: PJA1 praja 1".
- ↑ Sasaki, Aya; Masuda Yoshiko; Iwai Kazuhiro; Ikeda Kyoji; Watanabe Ken (Jun 2002). "A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1". J. Biol. Chem. (United States) 277 (25): 22541–6. doi:10.1074/jbc.M109728200. ISSN 0021-9258. PMID 11959851.
Further reading
- Mishra L, Tully RE, Monga SP, et al. (1997). "Praja1, a novel gene encoding a RING-H2 motif in mouse development". Oncogene 15 (19): 2361–8. doi:10.1038/sj.onc.1201405. PMID 9393880.
- Fang S, Jensen JP, Ludwig RL, et al. (2000). "Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53". J. Biol. Chem. 275 (12): 8945–51. doi:10.1074/jbc.275.12.8945. PMID 10722742.
- Sasaki A, Masuda Y, Iwai K, et al. (2002). "A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1". J. Biol. Chem. 277 (25): 22541–6. doi:10.1074/jbc.M109728200. PMID 11959851.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
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